氧雾化吸入含钾药物在纠正腹膜透析患者低钾中的临床应用效果  

Clinical Effect of Oxygen Atomization Inhalation of Potassium-containing Drugs in Correcting Hypokalemia in Patients with Peritoneal Dialysis

作　　者：吴云 谭浅 何贵珍 WU Yun;TAN Qian;HE Guizhen(The Third People’s Hospital of Jingdezhen,Jiangxi Province,Jingdezhen 333000,China;不详)

机构地区：[1]江西省景德镇市第三人民医院,江西景德镇333000

出　　处：《中国医学创新》2022年第17期9-13,共5页Medical Innovation of China

基　　金：景德镇市科技计划项目(20201SFZC038)。

摘　　要：目的:探讨氧雾化吸入含钾药物在纠正腹膜透析患者低钾中的应用效果。方法:选取2020年9月-2021年6月景德镇市第三人民医院收治的60例腹膜透析患者为研究对象,按随机数字表法分为对照组和观察组,各30例。对照组予以口服氯化钾缓释片治疗,观察组则将氯化钾注射液加入生理盐水内行氧驱动雾化吸入治疗,与透析同步进行。对比两组血钾浓度恢复到3.5 mmol/L时间、血钾浓度改善情况、营养不良指标、肾功能、不良反应。结果:观察组血钾浓度恢复到3.5 mmol/L的平均时间为(8.43±1.59)h,短于对照组的(10.24±2.07)h,差异有统计学意义(P<0.05)。治疗前,两组血钾浓度相比,差异无统计学意义(P>0.05);治疗1、2、3 d后,观察组血钾浓度分别为(3.95±0.51)mmol/L、(4.26±0.65)mmol/L、(4.69±0.73)mmol/L,均高于对照组的(3.62±0.42)mmol/L、(3.81±0.58)mmol/L、(4.14±0.61)mmol/L,差异均有统计学意义(P<0.05)。治疗前,两组血清白蛋白(Alb)、转铁蛋白(Tf)、血浆前白蛋白(PA)、尿素氮(BUN)、血肌酐(Scr)、血尿酸(SUA)水平相比,差异均无统计学意义(P>0.05);治疗3 d后,观察组Alb、Tf、PA水平分别为(41.75±4.64)g/L、(3.89±0.83)g/L、(486.57±19.43)mg/L,均高于对照组的(36.59±4.26)g/L、(3.25±0.72)g/L、(452.96±18.65)mg/L,BUN、Scr、SUA水平分别为(13.17±1.58)mmol/L、(233.61±11.46)μmol/L、(409.95±27.45)μmol/L,均低于对照组的(15.45±2.08)mmol/L、(254.83±13.84)μmol/L、(542.57±30.27)μmol/L,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:氧雾化吸入氯化钾能够有效促进腹膜透析患者的血钾浓度恢复,既可纠正低钾情况,又可改善缺氧症状,从而有效改善患者机体营养不良状态,显著提高肾功能,且不会增加不良反应,安全可靠,值得临床的大力推行。Objective:To investigate the application effect of oxygen atomization inhalation of potassium-containing drugs in correcting hypokalemia in patients with peritoneal dialysis.Method:A total of 60 patients with peritoneal dialysis admitted to the Third People’s Hospital of Jingdezhen from September 2020 to June 2021 were selected as the study subjects,and they were divided into the control group and the observation group,according to random number table method,with 30 patients in each group.The control group was treated with oral Potassium Chloride Sustained Release Tablets,while the observation group was treated with Potassium Chloride Injection added into normal saline for oxygen-driven atomization inhalation,which was carried out simultaneously with dialysis.The recovery time of serum potassium concentration to 3.5 mmol/L,improvement of serum potassium concentration,malnutrition indicators,renal function and adverse reactions were compared between the two groups.Result:The average time for the serum potassium concentration to recover to 3.5 mmol/L in the observation group was(8.43±1.59)h,which was shorter than(10.24±2.07)h in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in serum potassium concentration between the two groups(P>0.05);at 1,2 and 3 d after treatment,the serum potassium concentrations of the observation group were(3.95±0.51)mmol/L,(4.26±0.65)mmol/L,(4.69±0.73)mmol/L,respectively,higher than(3.62±0.42)mmol/L,(3.81±0.58)mmol/L,(4.14±0.61)mmol/L of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in serum albumin(Alb),transferrin(Tf),plasma prealbumin(PA),urea nitrogen(BUN),serum creatinine(Scr)and serum uric acid(SUA)between two groups(P>0.05);after 3 d of treatment,the levels of Alb,Tf and PA in the observation group were(41.75±4.64)g/L,(3.89±0.83)g/L,(486.57±19.43)mg/L,respectively,higher than(36.59±4.26)g/L,(3.25±0.72)g/L,(452.9

关 键 词：腹膜透析 氧驱动雾化吸入 血钾 不良反应 

分 类 号：R692.5[医药卫生—泌尿科学]