Syntaxin17在自噬膜融合中的作用及调控机制的研究进展  

Research progress of syntaxin17 in autophagy membrane fusion and its regulatory mechanism

作　　者：赵玉梦 曲华艺 卞宇生 刘宗平[1,2] 邹辉 ZHAO Yu-meng;QU Hua-yi;BIAN Yu-sheng;LIU Zong-ping;ZOU Hui(College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou 225009,China)

机构地区：[1]扬州大学兽医学院,江苏扬州225009 [2]江苏省动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009

出　　处：《中国兽医科学》2022年第4期531-536,共6页Chinese Veterinary Science

基　　金：国家自然科学基金资助项目(31702305);江苏高校优势学科建设工程资助项目(PAPD)。

摘　　要：自噬是一种细胞自我降解和循环利用胞内组分的过程,对细胞应对外界环境变化、维持自身稳态至关重要。目前有关自噬的作用与机制已经有了广泛的研究,SNARE蛋白(SNAREs)参与自噬的整个过程,是自噬过程中物质运输及膜融合的关键蛋白。Syntaxin17(STX17)是SNARE蛋白中重要的蛋白之一,也是目前研究较为广泛的一个蛋白。本文将近年来STX17对自噬调控的相关进展进行综述,为后续研究自噬的机制提供参考。Autophagy is a process in which cells self-degrade and recycle intracellular components,which is crucial for cells to cope with environmental changes and maintain homeostasis.At present,there have been extensive studies on the role and mechanism of autophagy.SNARE proteins(SNAREs)participates in the whole process of autophagy and is the key protein of substance transport and membrane fusion in autophagy.Syntaxin17(STX17)is one of the most important proteins in SNAREs,and is also one of the most widely studied proteins.This paper reviews the progress of the regulation of STX17 in autophagy in recent years to provide reference for the subsequent study on the mechanism of autophagy.

关 键 词：自噬 SNARE蛋白 STX17 膜融合 

分 类 号：S852.23[农业科学—基础兽医学]