甲巯咪唑与131I治疗老年甲亢的疗效分析  

Efficacy analysis of methimazole and ^(131)I in the treatment of senile hyperthyroidism

作　　者：袁顺 YUAN Shun(Endocrine Department,Suizhong County Hospital,Huludao 125200,China)

机构地区：[1]辽宁省绥中县医院内分泌科,125200

出　　处：《中国现代药物应用》2022年第9期140-142,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析甲巯咪唑与放射性核素碘131(^(131)I)治疗老年甲状腺功能亢进症(甲亢)的临床疗效。方法70例老年甲亢患者,随机分为对照组和观察组,各35例。对照组患者采用甲巯咪唑治疗,观察组患者采用^(131)I治疗。比较两组患者治疗前后甲状腺指标[三碘甲状腺原氨酸(T_(3))、甲状腺素(T_(4))、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))]、治疗效果、不良反应发生情况及复发率。结果治疗前,两组患者T_(3)、T_(4)、FT_(3)、FT_(4)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者T_(3)、T_(4)、FT_(3)、FT_(4)水平均低于治疗前,且观察组T_(3)、T_(4)、FT_(3)、FT_(4)水平显著低于对照组,差异具有统计学意义(P<0.05)。观察组治疗总有效率为100.00%,显著高于对照组的74.29%,差异具有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。随访2年,观察组停药后1年内复发率5.71%显著低于对照组的22.86%,差异具有统计学意义(P<0.05)。结论^(131)I治疗老年甲亢的临床疗效优于甲巯咪唑,且可更好的改善患者甲状腺功能,降低复发率,安全性高,具有临床推广价值。Objective To analyze the clinical efficacy of methimazole and radionuclide iodine 131(^(131)I)in the treatment of senile hyperthyroidism.Methods A total of 70 elderly patients with hyperthyroidism were randomly divided into control group and observation group,with 35 cases in each group.Patients in the control group were treated with methimazole,and patients in the observation group were treated with ^(131)I.Both groups were compared in terms of thyroid indexes[triiodothyronine(T3),thyroxine(T4),free triiodothyronine(FT3),free thyroxine(FT4)],therapeutic effect,incidence of adverse reactions and recurrence rate.Results Before treatment,there was no statistically significant difference in the levels of T3,T4,FT3 and FT4 between the two groups(P>0.05).After treatment,the levels of T3,T4,FT3,and FT4 in the two groups were lower than those of this group before treatment,and the levels of T3,T4,FT3,and FT4 in the observation group were significantly lower than those in the control group.All the differences were statistically significant(P<0.05).The total effective rate of the observation group was 100.00%,which was significantly higher than 74.29%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 2 years of follow-up,the recurrence rate within 1 year after drug withdrawal in the observation group was 5.71%,which was significantly lower than 22.86%in the control group,and the difference was statistically significant(P<0.05).Conclusion 131I is more effective than methimazole in the treatment of senile hyperthyroidism,and can improve thyroid function of patients,reduce recurrence rate and has high safety,which has clinical popularization value.

关 键 词：甲巯咪唑 放射性核素碘131 甲状腺功能亢进症 甲状腺功能 临床疗效 

分 类 号：R581.1[医药卫生—内分泌]