乌司他丁联合持续血液滤过治疗急性肾损伤的效果及对患者尿IL-18、血清胱抑素C的影响  

Effect of ulinastatin combined with continuous hemofiltration in the trea tment of acute kidney injury and its effect on urinary IL-18 and serum cystatin C

作　　者：黎明 LI Ming(Hebei Dingzhou People’s Hospital,Dingzhou 073000,China)

机构地区：[1]河北省定州市人民医院,河北定州073000

出　　处：《当代医药论丛》2022年第13期109-111,共3页

摘　　要：目的:探讨用乌司他丁联合持续血液滤过疗法治疗急性肾损伤的效果及对患者尿IL-18、血清胱抑素C水平的影响。方法:选取2018年1月至2021年2月河北省定州市人民医院接诊的急性肾损伤患者90例,采用双色球法将其分为研究组(45例)和对照组(45例)。对对照组患者进行常规治疗+持续血液滤过治疗,在此基础上为研究组患者采用乌司他丁进行治疗。然后对比两组患者的APACHEⅡ评分、SCr、BUN、血清胱抑素C(CysC)及尿IL-18的水平。结果:(1)治疗前,两组患者的APACHEⅡ评分、SCr、BUN的水平相比,差异无统计学意义(P>0.05)。治疗后,两组患者的APACHEⅡ评分、SCr、BUN的水平均较治疗前显著降低,差异有统计学意义(P<0.05);研究组患者的APACHEⅡ评分、SCr、BUN的水平均低于对照组患者,差异有统计学意义(P<0.05)。(2)治疗前,两组患者血清CysC的水平、尿IL-18的水平相比,差异无统计学意义(P>0.05)。治疗后,两组患者血清CysC的水平、尿IL-18的水平均较治疗前显著降低,差异有统计学意义(P<0.05);研究组患者血清CysC的水平、尿IL-18的水平均低于对照组患者,差异有统计学意义(P<0.05)。结论:用乌司他丁联合持续血液滤过疗法治疗急性肾损伤可显著改善患者的病情,降低其血清CysC、尿IL-18的水平。Objective:To investigate the effect of ulinastatin combined with continuous hemofiltration therapy in the treatment of acute kidney injury and the influence of urinary IL-18 and serum cystatin C levels.Methods:A total of 90 patients with acute kidney injury admitted to Dingzhou People’s Hospital of Hebei Province from January 2018 to February 2021 were selected and divided into study group(45 cases)and control group(45 cases)by bicolor method.Patients in the control group received conventional treatment plus continuous hemofiltration,and patients in the study group received ulinastatin on this basis.Then APACHEⅱscore,SCr,BUN,serum cystatin C(CysC)and urine IL-18 levels were compared between 2 groups.Results:(1)Before treatment,there were no significant differences in APACHEⅱscore,SCr and BUN levels between 2 groups(P>0.05).After treatment,the levels of APACHEⅱscore,SCr and BUN in 2 groups were significantly decreased compared with before treatment,the differences were statistically significant(P<0.05);The levels of APACHEⅱscore,SCr and BUN in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).(2)Before treatment,there were no significant differences in serum CysC level and urine IL-18 level between 2 groups(P>0.05).After treatment,the level of serum CysC and urine IL-18 in 2 groups were significantly decreased compared with before treatment,the differences were statistically significant(P<0.05).The serum CysC level and urinary IL-18 level of patients in the study group were lower than those in the control group,with statistical significance(P<0.05).Conclusion:Ulinastatin combined with continuous hemofiltration therapy can s ignificantly improve the severity of acute kidney injury and reduce the levels of serum CysC and urine IL-18.

关 键 词：急性肾损伤 乌司他丁 持续血液滤过 尿IL-18 血清胱抑素C 

分 类 号：R692[医药卫生—泌尿科学]