我市3851例待孕女性TPO-Ab、TSH、FT_(4)检测结果的分析  

Analysis of TPO-AB,TSH and FT 4 test results of 3851 pregnant women in our city

作　　者：龚艳会 马海东 GONG Yanhui;MA Haidong(Department of Clinical Laboratory,Dingxi People’s Hospital of Gansu Pro vince,Dingxi Gansu 743000)

机构地区：[1]甘肃省定西市人民医院检验科,甘肃定西743000

出　　处：《当代医药论丛》2022年第13期137-140,共4页

摘　　要：目的:分析定西市3851例待孕女性甲状腺过氧化物酶抗体(TPO-Ab)、促甲状腺激素(TSH)、游离甲状腺激素(FT4)的检测结果,了解该地区待孕女性甲状腺疾病的发病情况和特点,为孕前、孕后甲状腺疾病的预防、诊断和治疗提供重要依据。方法:回顾性分析2019年7月至2021年7月在定西市人民医院产科门诊进行孕前检查的3581例待孕女性的相关资料,对其TPO-Ab、TSH、FT4的检测结果进行统计分析。结果:3851例待孕女性甲状腺功能异常的检出率为22.28%,其中以TPO-Ab异常为主,TPO-Ab异常的女性占甲状腺功能异常人数的55.76%,其次以亚临床甲状腺功能减退症和亚临床甲状腺功能亢进症女性居多。待孕女性的年龄、孕产史、体质指数、甲状腺疾病家族史对其甲状腺功能均有影响(P<0.05)。在这些待孕女性中,血清TSH>2.5 mU/L的女性占35.5%。TPO-Ab抗体水平与TSH水平相关(P<0.05),与FT4水平无关(P>0.05)。结论:通过检测定西市待孕女性TPO-Ab、TSH、FT4的水平,发现其甲状腺功能异常的发病率偏高,多表现为TPO-Ab升高、亚临床甲状腺功能减退症和亚临床甲状腺功能亢进症。对甲状腺疾病筛查结果异常的待孕女性要有针对性地实施早期干预,尤其要重视TPO-Ab抗体的监测,以避免妊娠后对母婴造成危害。objective:to analyze 3851 cases of dingxi city for pregnant women of thyroid peroxidase antibodies(TPO-Ab)and testing for thyroid-stimulating hormone(TSH),free thyroid hormones(FT4)test results,to understand the region to be thyroid disease incidence and characteristics of the pregnant women for pregnancy,pregnancy after thyroid disease prevention,diagnosis and treatment to provide important basis.Methods:The data of 3581 pregnant women who underwent pre-pregnancy examination in the department of Obstetrics of Dingxi People’s Hospital from July 2019 to July 2021 were retrospectively analyzed,and the test results of TPO-AB,TSH and FT4 were statistically analyzed.Results:The detection rate of thyroid dysfunction in 3851 pregnant women was 22.28%,tPO-AB abnormality was the main one,tPO-AB abnormality accounted for 55.76%of the number of thyroid dysfunction,followed by subclinical hypothyroidism and subclinical hyperthyroidism.Age,pregnancy history,body mass index and family history of thyroid disease had significant effects on thyroid function of pregnant women(P<0.05).Among these pregnant women,serum TSH>2.5 mU/L accounted for 35.5%.Tpo-ab antibody level was correlated with TSH level(P<0.05),but not with FT4 level(P>0.05).Conclusion:By detecting the levels of Tpo-AB,TSH and FT4 of expectant pregnant women in Dingxi City,it was found that the incidence of thyroid dysfunction was high,mainly manifested as elevated Tpo-Ab,subclinical hypothyroidism and subclinical hyperthyroidism.Early intervention should be carried out for pregnant women with abnormal thyroid disease screening results,especially the monitoring of TPO-AB antibody,so as to avoid harm to mother and baby after pregnancy.

关 键 词：待孕女性 甲状腺过氧化物酶抗体 促甲状腺激素 游离甲状腺激素 甲状腺疾病 

分 类 号：R715[医药卫生—妇产科学]