邻巯基苯甲醛与β,γ-不饱和-α-酮酸酯的Michael加成/aldol/内酯化串联反应的研究  

Michael/Aldol/Lactonization Cascade Reaction of 2-Mercaptobenzaldehyde andβ,γ-Unsaturated-α-Ketoesters

作　　者：张学环 叶玲 李雪锋[1] Zhang Xuehuan;Ye Ling;Li Xuefeng(School of Chemistry and Environmental,Southwest Minzu University,Chengdu 610041,China;Faculty of Geoseiences and Environmental Engineering,Southwest Jiaotong University,Chengdu 610031,China)

机构地区：[1]西南民族大学化学与环境学院,四川成都610041 [2]西南交通大学地球科学与环境工程学院,四川成都610031

出　　处：《山东化工》2022年第10期22-23,27,共3页Shandong Chemical Industry

基　　金：中央高校基本科研业务费专项资金:西南交通大学(2682020CX13);西南民族大学2021年校级大学生创新创业训练计划项目(X201110656378)。

摘　　要：在碳酸钠的作用下,邻巯基苯甲醛能够顺利与β,γ-不饱和-α-酮酸酯发生Michael加成/aldol/内酯化串联反应,以50%~60%的产率得到目标产物。反应表现出较好的底物适应性,各种电子性质的β,γ-不饱和-α-酮酸酯都能够与邻巯基苯甲醛顺利发生串联反应。所有的目标产物结构都经^(1)H-NMR、^(13)C-NMR确认。A sulfa-Michael/aldol/lactonization cascade reaction has been developed to construct isotetronic acid-fused thiochromanes in a stereoselective fashion.The tricyclic products were obtained in 50%~60% isolated yields with sodium carbonate.The structures of the tricyclic products were unambiguously characterized by ^(1)H NMR and ^(13)C NMR analysis.

关 键 词：串联反应 β γ-不饱和-α-酮酸酯 邻巯基苯甲醛 

分 类 号：TQ201[化学工程—有机化工] O621.251[理学—有机化学]