25(OH)D水平对高血压合并冠心病患者心肌重构及左心室舒张功能的影响  

Effect of 25(OH)D level on myocardial remodeling and diastolic function in patients with hypertension complicated with coronary heart disease

作　　者：黄文霞[1] 李海涛[1] 黄玉冰[1] 廖旺[1] HUANG Wenxia;LI Haitao;HUANG Yubing;LIAO Wang(Department of Cardiovascular Medicine,Hainan Hospital,Hainan Medical College&Hainan Provincial People's Hospital,Haikou 570311,Hainan,China)

机构地区：[1]海南省人民医院海南医学院附属海南医院心血管内科,海南省海口市570311

出　　处：《中南医学科学杂志》2022年第4期521-524,共4页Medical Science Journal of Central South China

基　　金：海南省自然科学基金项目(814319)。

摘　　要：目的分析25羟基维生素D[25(OH)D]水平对高血压合并冠心病患者心肌重构及左心室舒张功能的影响。方法选择80例高血压合并冠心病患者,根据左心室质量指数及左心室舒张功能分为心肌重构组和无心肌重构组、舒张功能障碍组和无舒张功能障碍组。Logistic回归分析影响高血压合并冠心病患者心肌重构及左心室舒张功能的独立危险因素,ROC曲线分析其诊断效能。结果与无心肌重构组比较,心肌重构组收缩压、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)升高,25(OH)D降低(P<0.05)。与无舒张功能障碍组比较,舒张功能障碍组体质指数(BMI)、25(OH)D水平降低,LDLC升高(P<0.05)。25(OH)D是患者心肌重构及左心室舒张功能的危险因素(P<0.05)。25(OH)D水平对患者心肌重构、舒张功能障碍有较好的诊断效能。结论25(OH)D水平是影响高血压合并冠心病患者心肌重构及左心室舒张功能的独立危险因素,早期检测其水平有助于临床诊疗。Aim To analyze the influence of 25-hydroxyvitamin D[25(OH)D]level on myocardial remodeling and left ventricular diastolic function in patients with hypertension complicated with coronary heart disease.Methods 80 patients with hypertension complicated with coronary heart disease were collected and divided into myocardial remodeling group and no myocardial remodeling group,diastolic dysfunction group and non-diastolic dysfunction group according to left ventricular mass index and left ventricular diastolic function.The independent risk factors affecting cardiac remodeling and left ventricular diastolic function in patients were analyzed by Logistics regression,and the diagnostic efficacy was studied by ROC curve.Results Compared with no-myocardial remodeling group,the levels of systolic blood pressure,total cholesterol(TC)and low-density lipoprotein cholesterol(LDLC)in the muscle remodeling group increased and 25(OH)D decreased(P<0.05).Compared with the non-diastolic dysfunction group,the levels of body mass index(BMI)and 25(OH)D in the diastolic dysfunction group decreased,and LDLC increased(P<0.05).25(OH)D level was a risk factor for both myocardial remodeling and diastolic dysfunction in patients(P<0.05).25(OH)D level has good diagnostic efficacy for myocardial remodeling and diastolic dysfunction.Conclusion 25(OH)D level is an independent risk factor for cardiac remodeling and left ventricular diastolic function in patients with hypertension complicated with coronary heart disease,and early detection of 25(OH)D level is helpful for clinical diagnosis.

关 键 词：25羟基维生素D 心肌重构 高血压 左心室舒张功能 冠心病 

分 类 号：R544.1[医药卫生—心血管疾病]