玉林市2017—2019年新生儿呼吸道细菌感染分布及多重耐药菌耐药调查  

Distribution of neonatal respiratory tract bacterial infections and multi drug-resistant bacteria in Yulin from 2017 to 2019

作　　者：梁武华[1] 梁敏煜 周海燕[1] LIANG Wuhua;LIANG Minyu;ZHOU Haiyan(Department of Neonatology,Maternal and Child Health Hospital,Yulin 537000,Guangxi,China;Department of Clinical Medicine,Jilin Medical University,Jilin 132000,Jilin,China)

机构地区：[1]玉林市妇幼保健院新生儿科,广西壮族自治区玉林市537000 [2]吉林医药学院临床医学部,吉林省吉林市132000

出　　处：《中南医学科学杂志》2022年第4期560-563,共4页Medical Science Journal of Central South China

基　　金：玉林市科学研究与技术开发项目(20171635)。

摘　　要：目的调查玉林市2017—2019年新生儿呼吸道感染的病原菌分布和耐药情况。方法以2017—2019年玉林市7家医院收治的1594例呼吸道感染新生儿为研究对象,收集其痰液样本进行菌株分布及耐药性分析。结果共分离出病原菌菌株1400株(87.83%),排名前五位依次为肺炎克雷伯菌、大肠埃希菌、金黄色葡萄球菌、鲍曼不动杆菌、铜绿假单胞菌。检出多重耐药菌688株,排名前三位为产超广谱β-内酰胺酶(ESBLS)肺炎克雷伯菌、耐碳青霉烯类鲍曼不动杆菌、产-ESBLS大肠埃希菌。产-ESBLS肺炎克雷伯菌对妥布霉素、左氧氟沙星敏感。耐碳青霉烯类鲍曼不动杆菌对替加环素及阿卡米星高度敏感。结论新生儿呼吸道感染的病原菌以革兰氏阴性菌为主,多重耐药菌以产-ESBLS为主。Aim To investigate the distribution and drug resistance of pathogenic bacteria in neonatal respiratory tract bacterial infections in Yulin from 2017 to 2019.Methods A total of 1594 neonates with respiratory tract infection from 7 hospitals in Yulin from 2019 to 2021 were selected as the research object,which sputum samples were collected and monitored for bacterial distribution and drug resistance.Results A total of 1400 strains of pathogenic bacteria(87.83%)were isolated,the top five pathogens were Klebsiella pneumoniae,Escherichia coli,Acinetobacter baumannii,Staphylococcus aureus,and Pseudomonas aeruginosa.688 strains of multidrug-resistant bacteria were detected,and the top three were extended-spectrumβ-lactamase(ESBLS)-producing Klebsiella pneumoniae,carbapenem-resistant Acinetobacter baumannii,and ESBLS-producing Escherichia coli.ESBLS-producing Klebsiella pneumoniae is sensitive to tobramycin,and levofloxacin.Carbapene-resistant Acinetobacter baumannii is sensitive to tigecycline and akamicin.Conclusion The pathogenic bacteria of neonatal respiratory tract infection are mainly gram-negative bacteria and the multi-drug resistant bacteria were mainly ESBLS-producing.

关 键 词：新生儿 呼吸道感染 多重耐药菌 

分 类 号：R725.6[医药卫生—儿科]