尿Ⅳ-C、mALB和血清FIB对儿童HSP合并肾小球损伤诊断及预后的预测  

Urinary Ⅳ-C, mALB and serum FIB in the diagnosis and prognosis of children with henoch schonlein purpura and glomerular injury

作　　者：杨庆 张冬梅 应海燕 解彪 YANG Qing;ZHANG Dongmei;YING Haiyan;XIE Biao(Department of Neonatology,Hanzhong 3201 Hospital,Hanzhong 723000,Shaanxi,China)

机构地区：[1]汉中市三二〇一医院新生儿科,陕西省汉中市723000

出　　处：《中南医学科学杂志》2022年第4期595-598,共4页Medical Science Journal of Central South China

摘　　要：目的研究尿Ⅳ胶原蛋白(Ⅳ-C)、微量白蛋白(mALB)和血清纤维蛋白原(FIB)水平对儿童过敏性紫癜(HSP)合并肾小球损伤诊断及预后的预测价值。方法选择HSP合并肾小球损伤患者为合并肾损伤组,单纯HSP患者为HSP组,健康志愿者为对照组,每组120例。比较不同肾功能、不同预后患者尿Ⅳ-C、mALB和血清FIB水平,分析尿Ⅳ-C、mALB和血清FIB联合检测对HSP合并肾小球损伤诊断及预后的诊断效能。结果患者尿Ⅳ-C、mALB和血清FIB水平从高到低依次为合并肾损伤组、HSP组、健康组,或肾功能损伤重度组、中度组、轻度组(P<0.05)。治疗有效组患者尿Ⅳ-C、mALB和血清FIB水平显著低于无效组(P<0.05)。尿Ⅳ-C、mALB和血清FIB联合检测对HSP合并肾小球损伤的诊断及预后的特异度和ROC曲线下面积显著高于单独检测。结论尿Ⅳ-C、mALB和血清FIB联合检测对儿童HSP合并肾小球损伤的诊断及预后的预测价值较高,可作为临床诊断的重要手段。Aim To study the diagnostic and prognostic value of urinaryⅣcollagen(Ⅳ-C),microalbumin(mALB)and serum fibrinogen(FIB)levels in children with henoch-schonlein purpura(HSP)and glomerular injury.Methods The patients with HSP and glomerular injury were the combined renal injury group,the patients with simple HSP were the HSP group,the healthy volunteers were the healthy group,with 120 cases in each group.The urineⅣ-C,mALB and serum FIB levels were compared among the patients with different renal functions and prognoses,and the efficacy of combined detection of urinaryⅣ-C,mALB and serum FIB levels in the diagnosis and prognosis of HSP complicated with renal injury were analyzed.Results The urinaryⅣ-C,mALB and serum FIB levels from high to low were the combined renal injury group>HSP group>healthy group,and these levels in patients with different renal functions from high to low were the severe group>moderate group>mild group(P<0.05).The levels of urinaryⅣ-C,mALB and serum FIB in the effective group were significantly lower than those in the ineffective group(P<0.05).The specificity and area under ROC curve of combined detection of urinaryⅣ-C,mALB and serum FIB in the diagnosis and prognosis of HSP complicated with glomerular injury were significantly higher than those detected alone.Conclusion The predictive value of combined detection of urinaryⅣ-C,mALB and serum FIB for the diagnosis and prognosis of children with HSP and glomerular injury is better,which can be used as an important basis for clinic diagnosis.

关 键 词：Ⅳ-C MALB FIB 过敏性紫癜 肾小球损伤 儿童 

分 类 号：R593.1[医药卫生—内科学]