细胞焦亡与糖尿病血管并发症关系的研究进展  

Association between pyroptosis and vascular complications of diabetes

作　　者：袁静雅 彭慧芳 张颖裕 雷方[1] 姜宏卫[1] Yuan Jingya;Peng Huifang;Zhang Yingyu;Lei Fang;Jiang Hongwei(College of Clinical Medicine of Henan University of Science and Technology,Department of Metabolism and Endocrinology,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang sub-center of National Clinical Research Center for Metabolic Diseases,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院、河南科技大学第一附属医院内分泌代谢科、国家代谢性疾病临床医学研究中心洛阳分中心,471003

出　　处：《国际内分泌代谢杂志》2022年第3期207-210,共4页International Journal of Endocrinology and Metabolism

摘　　要：糖尿病血管病变是主要的糖尿病慢性并发症,是导致患者生活质量下降和预期寿命缩短的最主要原因。细胞质内模式识别受体(PRRs)可感受多种刺激形成炎性小体,激活焦亡通路,加重糖尿病患者代谢紊乱,促进糖尿病血管并发症的发生发展。本文浅谈细胞焦亡对不同糖尿病血管并发症的促进作用,以及抑制焦亡通路可能为糖尿病血管并发症的早期诊治提供新的思路。Diabetic vascular complications are the main chronic complications of diabetes,which is the main reason for the loss of quality of life and the shortening of life expectancy in diabetic patients.Pattern recognition receptors(PRRs)can sense stimulation to form inflammasomes,which activates the pyroptosis pathway,aggravates the metabolic disorder of diabetic patients,and promotes the occurrence and development of diabetic vascular complications.This article systematically reviews the promoting effect of pyroptosis on the vascular complications of diabetes,and inhibiting the pyroptosis pathway may provide new ideas for the early diagnosis and treatment of diabetic vascular complications.

关 键 词：细胞焦亡 炎性小体 糖尿病血管并发症 

分 类 号：R587.2[医药卫生—内分泌]