婴儿巨大型幼年黄色肉芽肿1例  

Giant Juvenile Xanthogranuloma in an Infant:A Case Report

作　　者：卢红铮 马琳[2] 张斌[2] LU Hongzheng;MA Lin;ZHANG Bin(Department of Dermatology,Children's Hospital Affiliated of Zhengzhou University,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou 450000,China;Department of Dermatology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China)

机构地区：[1]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院皮肤科,河南郑州450000 [2]首都医科大学附属北京儿童医院(国家儿童医学中心)皮肤科,北京100045

出　　处：《中国皮肤性病学杂志》2022年第6期712-715,共4页The Chinese Journal of Dermatovenereology

基　　金：北京市医院管理中心儿科学科协同发展中心专项(XTZD20180502);北京市自然科学基金(7222058)。

摘　　要：患儿女,9月龄,右面部肿物生后即有,渐增大。皮肤科情况:右面部可见一橘黄色半球形肿物,2 cm×3 cm大小,境界清楚,质地坚韧,表面橘皮样改变。皮损组织病理示:真皮全层弥漫的泡沫状组织细胞浸润,可见典型Touton巨细胞。免疫组织化学染色示:CD68、CD163、Fascin均阳性,CD1a、S-100均阴性。BRAF^(V600E)未检出突变。诊断:幼年黄色肉芽肿。未予特殊治疗,活检术后患儿皮损较前明显萎缩干瘪,目前仍在随访中。A 9-month-old infant presented with a tumor on the right face after birth and gradually increased.Dermatological examination showed an orange hemispherical tumor on the right face,about 2 cm×3 cm in size,with clear boundary,hard nodules,and orange peel-like changes on the surface.Histopathology of the lesion showed that diffuse infiltration of foam cells in the dermis.Typical Touton giant cells were seen.Immunohistochemical staining showed that CD68,CD163 and Fascin were positive;CD1a and S-100 were negative.No mutation was detected in BRAF^(V600E).The diagnosis of giant juvenile xanthogranuloma was made.No treatment was given and the nodules became smaller during follow-up.

关 键 词：幼年黄色肉芽肿 巨大型 婴儿 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]