皮肤癌肉瘤1例  

Cutaneous Carcinosarcoma:A Case Report

作　　者：黄思琪 于波[1] 陈办成[1] HUANG Siqi;YU Bo;CHEN Bancheng(Department of Dermatology and Venereology,Peking University Shenzhen Hospital,Shenzhen 518036,China)

机构地区：[1]北京大学深圳医院皮肤性病科,广东深圳518036

出　　处：《中国皮肤性病学杂志》2022年第4期462-464,共3页The Chinese Journal of Dermatovenereology

基　　金：深圳市医学重点学科建设经费(SZXK040);深圳三名工程经费(SZSM201812059)。

摘　　要：患者女,34岁,左枕后肿物1月余。皮损组织病理示:(左枕后)镜检为恶性肿瘤,可见两种成分,一种为异型的鳞状上皮细胞巢,另一种瘤细胞呈梭形,弥漫或包绕血管生长,需鉴别肉瘤样癌与癌肉瘤。免疫组织化学示:巢团状分布的肿瘤细胞CK(+),p40(+);成片分布的肿瘤细胞Vimentin(+);Ki-67(+)热点区约50%,肿瘤细胞Desmin、S-100、GCDFP15、ERG、CD34均(-)。结合HE形态及免疫组织化学结果,符合皮肤癌肉瘤。诊断:皮肤癌肉瘤。行扩大切除术治疗。术后随访未见复发。A 34-year-old female patient with a swelling at the left posterior occipital for more than 1 month.The histopathology of excised tissue showed:microscopic examination of a malignant tumor(left occipital posterior)contains two components:one is a heterogeneous nest of squamous epithelial cells,and the other one is a spindle tumor with diffuse or vascular growth,requiring the differentiation of sarcomatoid carcinoma and carcinosarcoma.Immunohistochemistry of skin lesions showed CK(+)and p40(+);tumor cells with nest mass distribution.Vimentin(+)distributed tumor cells;Ki-67(+)hotspot was about 50%,and tumor cells Desmin,S-100,GCDFP15,ERG,and CD34 were negative.Combined HE morphology and immunohistochemical results,it was consistent with skin cancer sarcoma.Diagnosis:Cutaneous carcinosarcoma.Extensive surgical resection was performed.Ostoperative follow-up showed no recurrence.

关 键 词：皮肤肿瘤 皮肤癌肉瘤 皮肤外科 

分 类 号：R7.9.5[医药卫生—临床医学]