^(99)Tc^(m)-DTPA SPECT/CT在二例甲状腺相关性眼病患者活动期评估中的应用及文献复习  

Application of ^(99)Tc^(m)-DTPA SPECT/CT in the activity assessment in two patients with thyroid associated ophthalmopathy and literature review

作　　者：夏晓天[1,2] 胡帆 兰晓莉[1] 曹国祥[1] 曹卫[1] Xia Xiaotian;Hu Fan;Lan Xiaoli;Cao Guoxiang;Cao Wei(Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology Hubei Key Laboratory of Molecular Imaging,Wuhan 430022,China;Department of Nuclear Medicine,the People's Hospital of Honghu,Honghu,433299,China)

机构地区：[1]华中科技大学同济医学院附属协和医院核医学科,分子影像湖北省重点实验室,武汉430022 [2]洪湖市人民医院核医学科,洪湖433299

出　　处：《国际放射医学核医学杂志》2022年第2期125-128,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：2020年甲状腺中青年医师研究项目(中国健康促进基金会);分子影像湖北省重点实验室开放基金(2020FZYX016)。

摘　　要：笔者通过分析2例患者^(99)Tc^(m)-二亚乙基三胺五乙酸(DTPA)SPECT/CT眼眶显像的不同结果并结合文献复习, 简述该影像学方法在甲状腺相关性眼病(TAO)活动期评估中的应用价值。目前临床常用的TAO活动期评估方法主要是通过患者的症状做出临床活动性评分(CAS), 但轻、中度患者临床表现部分有重叠, 单纯使用CAS评分不易鉴别, 且该诊断具有一定主观性。通过病例分析, 结果显示, ^(99)Tc^(m)-DTPA SPECT/CT眼眶显像较CAS对非活动性TAO有着更高的阴性预测值, 这说明该显像也能成为TAO评估的一种选择。This paper briefly described the application value of this imaging method in the evaluation of active thyroid-related ophthalmopathy(TAO)by analyzing the different results of ^(99)Tc^(m)-diethylene triaminepentaacetic acid(DTPA)SPECT/CT orbital imaging in 2 patients and combined with literature review.At present,the commonly used clinical assessment of TAO active phase is mainly based on the clinical activity score(CAS)of the patient's symptoms,but the clinical manifestations of mild and moderate patients partially overlap,and it is not easy to identify using the CAS score alone,and the diagnosis is subject to a certain degree.The results of this study show that ^(99)Tc^(m)-DTPA SPECT/CT orbital imaging has a higher negative predictive value for inactive TAO than CAS,indicating that this imaging can also be an option for TAO assessment.

关 键 词：SPECT/CT 甲状腺相关性眼病 影像学方法 中度患者 TAO DTPA 文献复习 阴性预测值 

分 类 号：R581[医药卫生—内分泌] R771.3[医药卫生—内科学] R817.4[医药卫生—临床医学]