磷酸肌酸钠对急诊PCI患者术后MAU和尿NGAL、血清CysC水平及造影剂肾病发生率的影响  

Effects of creatine phosphate sodium on levels of microalbminurine, urine NGAL and serum CysC, and incidence of contrast-induced nephropathy in patients after emergency PCI

作　　者：王志谦 滕伟 王建民 何兆辉 马光 WANG Zhi-qian;TENG Wei;WANG Jian-Min;HE Zhao-hui;MA Guang(Department of cardiovascular medicine,The First Affiliated Hospital of Henan University,Kaifeng Henan 475000,China)

机构地区：[1]河南大学第一附属医院心血管内科,河南开封475000

出　　处：《中国卫生工程学》2022年第2期226-228,共3页Chinese Journal of Public Health Engineering

基　　金：2018年度河南省医学科技攻关计划普通项目(2018020315)。

摘　　要：目的 探讨磷酸肌酸钠对急诊经皮冠状动脉介入治疗(PCI)患者术后尿微量白蛋白(MAU)、尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、血清胱抑素C(CysC)水平及造影剂肾病发生率的影响。方法 选取2017年7月至2019年8月在本院行急诊PCI治疗的84例患者,随机数字表法将患者分为观察组和对照组,每组42例。对照组于PCI术前给予常规治疗,观察组于PCI术前给予磷酸肌酸钠治疗,观察两组术后MAU、尿NGAL、血清CysC水平变化及造影剂肾病发生率。结果 观察组术后24 h MAU和尿NGAL、血清CysC水平均优于对照组[(38.65±6.72)vs(49.21±7.06) mg/L、(26.55±7.86)vs(31.49±9.35) ng/ml、(0.87±0.26)vs(1.63±0.35)mg/L],组间比较差异均有统计学意义(均P<0.05)。观察组造无影剂肾病发生,发生率为0.00%(0/42),明显低于对照组的14.29%(6/42),两组造影剂肾病发生率比较差异有统计学意义(P<0.05)。结论 磷酸肌酸钠可明显改善急诊PCI患者术后MAU、尿NGAL、血清CysC水平,降低造影剂肾病发生率。Objective This paper aims to explore effects of creatine phosphate sodium(CPS) on levels of microalbminurine(MAU), urine neutrophil gelatinase-associated lipocalin(NGAL) and serum cystatin C(CysC), and incidence of contrast-induced nephropathy(CIN) in patients after emergency percutaneous coronary intervention(PCI).Methods A total of 84 patients who underwent emergency PCI in the hospital from July 2017 to August 2019 were enrolled. They were divided into observation group and control group by random number table method, with 42 cases in each group. Before PCI,The control group was given routine treatment, while the observation group was given CPS. The changes in levels of MAU, urine NGAL and serum CysC, and incidence of CIN after surgery in both groups were observed. Results The levels of MAU, urine NGAL and serum CysC in observation group were significantly better than those in control group[(38.65±6.72)vs(49.21±7.06) mg/L、(26.55±7.86)vs(31.49±9.35) ng/ml、(0.87±0.26)vs(1.63±0.35)mg/L](P<0.05). There were significant differences in incidence of adverse reactions between observation group and control group(0.00% vs 14.29%)(P<0.05).Conclusion CPS can significantly improve levels of MAU, urine NGAL and serum CysC, and decrease incidence of CIN in patients after emergency PCI.

关 键 词：冠状动脉介入治疗 磷酸肌酸钠 肾功能 

分 类 号：R692[医药卫生—泌尿科学]