一种胆酸类化合物Ⅳ的合成方法  

A Synthesis Method of Cholic Acid Compound Ⅳ

作　　者：刘晓斌 付敏 李传青 Liu Xiaobin;Fu Min;Li Chuanqing(Jiangxi Qingfeng Pharmaceutical Co.,Ltd.,Ganzhou 341000,China)

机构地区：[1]江西青峰药业有限公司,江西赣州341000

出　　处：《山东化工》2022年第11期4-6,共3页Shandong Chemical Industry

基　　金：多靶点癌症药物苹果酸卡博替尼的研发与产业化(20213BCJ22028)。

摘　　要：以去氧胆酸为起始物料,通过甲酯化反应、酰化反应、氧化反应和还原反应得到标题化合物,即3α-(4-甲氧基苯甲酰氧基)-12β-羟基-5β-胆烷-24-酸甲酯(简称化合物Ⅳ)。该化合物Ⅳ是一个新的化合物,属于胆酸类衍生物,和去氧胆酸具有相似的母核结构,采用本方法可快速制备得到该化合物Ⅳ,可以极大地缩短手性杂质对照品的制备时间,减少杂质对照品的分析难度,该化合物Ⅳ纯度99.58%,结构经^(1)H NMR、^(13)C NMR和MS分析得到确证。With deoxycholic acid as the starting material,the title compound,3α-(4-methoxybenzoyloxy)-12β-hydroxyl-5β-cholane-24-acid methyl ester(referred to as compound Ⅳ),is obtained through methyl esterification,acylation,oxidation and reduction reactions.This compound Ⅳ is a new compound,which belongs to cholic acid derivatives,and has a similar core structure to deoxycholic acid.The compound Ⅳ can be quickly prepared by this method.It can greatly shorten the preparation time of chiral impurity reference and reduce the difficulty of analysis of impurity reference.The purity of the compound Ⅳ is 99.58%.The structure was confirmed by ^(1)H NMR,^(13)C NMR and MS analysis.

关 键 词：胆酸类 化合物Ⅳ 合成 

分 类 号：O624.33[理学—有机化学]