尿苷二磷酸葡萄糖醛酸基转移酶介导的黄酮类化合物代谢研究进展  

Research Progress on the Metabolism of Flavonoids Mediated by UDP-glucuronosyltransferases

作　　者：苏圣迪 宁晨 任光辉 陈西敬 李霁 Su Shengdi;Ning Chen;Ren Guanghui;Chen Xijing;Li Ji(School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学基础医学与临床药学学院,江苏南京211198

出　　处：《山东化工》2022年第11期80-83,共4页Shandong Chemical Industry

摘　　要：黄酮类化合物广泛存在于膳食中,因具有多种生物活性,其在医药或食品工业中的应用也逐年增加。其在人体中主要经过由尿苷二磷酸葡萄糖醛酸基转移酶(UDP-glucuronosyltransferases,UGT)催化的Ⅱ相反应而代谢。除此之外,UGT在体内还介导了大量药物和天然化合物的代谢清除。本文总结了近年来新发现的黄酮类化合物UGT代谢研究的最新进展。Flavonoids are widely found in the diet.Their use in the pharmaceuticals or food industry is increasing year by year because of the multiple biological activities.They are metabolized in humans mainly through phase II reactions catalyzed by glucuronosyltransferases(UGTs).In addition,UGTs mediate the metabolic clearance of a large number of drugs and natural compounds in vivo.This review summarized the recent researches of UDP-glucuronosyltransferase-mediated metabolismstudies of newly discovered flavonoids.

关 键 词：黄酮 葡萄糖醛酸转移酶 药物代谢动力学 

分 类 号：R965.2[医药卫生—药理学]