新型脱矿同种骨修复材料的骨诱导活性研究  

Study on the Osteoinduction of New Type of Human Demineralized Bone Material

作　　者：尹曼莉 王耀宏 宋之言 YIN Manli;WANG Yaohong;SONG Zhiyan(Shanghai Lama Biological materials Co.Ltd.Shanghai,200444)

机构地区：[1]上海兰玛生物材料有限公司,上海200444

出　　处：《生物医学工程学进展》2022年第2期81-83,共3页Progress in Biomedical Engineering

摘　　要：目的研究一种新型脱矿同种骨修复材料的骨诱导活性。方法在裸鼠腿部肌肉内植入脱矿骨纤维材料,植入样品后第2周和第4周取材进行组织学形态观察和骨诱导活性研究。结果脱矿骨纤维植入裸鼠肌肉后2周,可见新生血管和软骨形成,植入4周后,可见多个新骨形成区。结论该种脱矿骨纤维具有明显的骨诱导效果,可作为一种较理想的临床骨修复材料。Objective To study the osteoinduction of one new type of human demineralized bone material(DBM).Methods The DBM fiber materials were implanted into hind-limb intermuscular sites of athymic rats.At 2 or 4 weeks after implantation,implanted materials were retrieved for histological observation and osteoinduction evaluation.Results At the 2-week time point,neovascularization and cartilage formation were observed.At 4-week time point,multiple new bone formation areas were observed.Conclusion The DBM fiber material shows a strong osteoinductive effect and can be used as an ideal bone-repairing material in clinics.

关 键 词：脱矿骨基质 脱矿骨纤维 裸鼠 骨诱导 

分 类 号：R318[医药卫生—生物医学工程]