症状性动脉导管未闭早产儿应用布洛芬治疗时不同奶量喂养方案对前列腺素E_(2)的影响  

Effect of different milk feeding regimen on prostaglandin E_(2) in premature infants with symptomatic patent ductus arteriosus treated with ibuprofen

作　　者：冯琳琳 李忠良[2] FENG Linlin;LI Zhongliang(Department of Pediatrics,Weifang Medical University,Weifang 261053,China;Neonatal Department of Weifang Maternal and Child Health Care Hospital)

机构地区：[1]潍坊医学院儿科学教研室,山东潍坊261053 [2]潍坊市妇幼保健院新生儿科

出　　处：《潍坊医学院学报》2022年第1期42-44,共3页Acta Academiae Medicinae Weifang

摘　　要：目的 探究不同奶量喂养方案在布洛芬治疗症状性动脉导管未闭(PDA)中对早产儿PGE;水平的影响。方法 选取我院2020年5月~2021年5月接收的PDA患儿100例,随机分为对照组和观察组,各50例。在常规使用布洛芬治疗的基础上,对照组给予高增幅奶量递增方案喂养,观察组给予低增幅奶量递增方案喂养,两组均给予治疗3d。观察两组患儿治疗后PDA的关闭情况,治疗前后两组患儿血、尿PGE;水平及治疗期间并发症发生情况。结果 治疗后,两组患儿PDA关闭情况比较,差异无统计学意义(P>0.05);与治疗前比较,治疗后两组患儿血、尿PEG2水平均降低(P<0.05),但组间比较,差异无统计学意义(P>0.05);治疗期间观察组患儿喂养不耐受、坏死性小肠结肠炎及消化道出血并发症发生情况明显低于对照组(P<0.05)。结论 布洛芬治疗PDA早产儿时,采用低增幅奶量递增方案喂养,不会影响布洛芬发挥治疗作用,进而不会影响药物治疗的闭合效果,同时并发症的发生情况减少,更为安全。Objective To explore the effect of different milk feeding regimens on PGE;levels in preterm infants with symptomatic patent ductus arteriosus(PDA) treated with ibuprofen.Methods One hundred children with PDA received in our hospital from May 2020 to May 2021 were selected and divided into control group and observation group according to the random number table method, with 50 cases in each group.On the basis of routine treatment with ibuprofen, the control group was fed with high milk increment scheme plan, and the observation group was fed with low milk increment scheme.Both groups were given treatment for 3 days.The closure of PDA after treatment, the blood and urine PGE;levels of children in both groups before and after treatment, and the occurrence of complications during treatment were observed in both groups.Results After treatment, there was no statistically significant difference in PDA closure between the two groups(P>0.05).Compared with treatment before, the levels of PEG2 in blood and urine of the two groups of children decreased after treatment(P<0.05),the difference was not statistically significant(P>0.05).During the treatment, the incidence of feeding intolerance, necrotizing enterocolitis and gastrointestinal bleeding complications in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Feeding of preterm infants with PDA using a low-increase incremental milk regimen does not affect the therapeutic effect of ibuprofen, which in turn does not affect the closure effect of the drug therapy, and the occurrence of complications is reduced and the treatment is safer.

关 键 词：动脉导管未闭 奶量 喂养 布洛芬 前列腺素E 

分 类 号：R722[医药卫生—儿科]