The composition,function,and regulation of adipose stem and progenitor cells  

作　　者：Xiyan Liao Haiyan Zhou Tuo Deng 

机构地区：[1]National Clinical Research Center for Metabolic Diseases,and Department of Metabolism and Endocrinology,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410000,China [2]Key Laboratory of Diabetes Immunology,Ministry of Education,and Metabolic Syndrome Research Center,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410000,China [3]Department of Endocrinology,Endocrinology Research Center,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [4]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha,Hunan 410008,China [5]Clinical Immunology Center,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410000,China

出　　处：《Journal of Genetics and Genomics》2022年第4期308-315,共8页遗传学报（英文版）

基　　金：supported by the National Key R&D Program of China (2020YFA0803604);the National Natural Science Foundation of China (81770868, 91742103, 82130024 and 82170866);the Science and Technology Innovation Program of Hunan Province (2020RC4009);the Project of Innovation-Driven Plan of Central South University (2020CX015)

摘　　要：White adipose tissue(WAT)is a highly plastic organ that plays a central role in regulating whole-body energy metabolism.Adipose stem and progenitor cells(ASPCs)are essential components of the stromal vascular fraction(SVF)of adipose tissue.They give rise to mature adipocytes and play a critical role in maintaining adipose tissue function.However,the molecular heterogeneity and functional diversity of ASPCs are still poorly understood.Recently,single-cell RNA sequencing(scRNA-seq)analysis has identified distinct subtypes of ASPCs in murine and human adipose tissues,providing new insights into the cellular complexity of ASPCs among multiple fat depots.This review summarizes the current knowledge on ASPC populations,including their markers,functions,and regulatory mechanisms.Targeting one or several of these cell populations may ameliorate metabolic disorders by promoting adaptive hyperplastic adipose growth.

关 键 词：Adipose tissue ASPC scRNA-seq Committed preadipocytes Regulatory progenitors 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]