基于苝酰亚胺的光开关荧光聚己内酯纳米粒子研究  

Study on Perylene Imide-based Photoswitchable Fluorescent Polycaprolactone Nanoparticles

作　　者：张玉彬 李想 李钰琪 姜佳伟 吴李琪 潘赫汝 张崇华 张培盛[1] 陈建[1] ZHANG Yu-bin;LI Xiang;LI Yu-qi;JIANG Jia-wei;WU Li-qi;PAN He-ru;ZHANG Chong-hua;ZHANG Pei-sheng;CHEN Jian(College of Chemistry and Chemical Engineering,Hunan University of Science and Technology,Xiangtan,Hunan 411201)

机构地区：[1]湖南科技大学化学化工学院理论有机化学与功能分子教育部重点实验室,湖南湘潭411201

出　　处：《胶体与聚合物》2022年第2期53-57,共5页Chinese Journal of Colloid & Polymer

基　　金：国家自然科学基金项目(51773056,52173278);湖南省杰出青年科学基金项目(2021JJ10029);湖南省自然科学基金青年项目,2021JJ40192。

摘　　要：光开关荧光聚合物纳米材料在荧光成像、生物传感和数据加密等领域的研究有着重要意义。本论文通过开环聚合首次合成了含苝酰亚胺的聚己内酯(TPDI-PCL)和含二芳基乙烯的聚己内酯(DTE-PCL)。基于荧光能量共振转移(FRET)原理,将TPDI-PCL和DTE-PCL通过共沉淀的方法构建了一种新型光开关荧光聚合物纳米粒子。通过两者合理的比例设计来调控体系的FRET效率,使纳米粒子具有良好的光开关荧光效果。另外,该纳米粒子还具有良好的水分散性,快速的光响应性和优异的光开关可逆性,以及由聚己内酯基质带来的良好的生物相容性和生物可降解性,可作为新型纳米探针直接应用于活体斑马鱼的可逆光开关荧光成像。Photoswitchable fluorescent polymer nanoparticles are of great significance in the fields of fluorescence imaging, biosensor and data encryption. In this paper, perylene imide-contained polycaprolactone(TPDI-PCL) and diarylethene-contained polycaprolactone(DTE-PCL) are firstly synthesized via ring-opening polymerization. Based on fluorescence resonance energy transfer(FRET)principle, TPDI-PCL and DTE-PCL are applied for constructing photoswitchable fluorescent polymer nanoparticles through coprecipitation. By regulating FRET efficiency with a reasonable proportion design,the nanoparticles can achieve a good photoswitching fluorescence effect. In addition, the nanoparticles also exhibit good water-dispersibility, rapid photoresponse and excellent photoswitching reversibility, as well as the good biocompatibility and biodegradability brought by the polycaprolactone matrix, which can be directly used as novel nano-probes for reversible phtoswitchable fluorescence imaging in living zebrafish.

关 键 词：光开关荧光 聚合物纳米粒子 荧光能量共振转移 苝酰亚胺 荧光成像 

分 类 号：TQ31[化学工程—高聚物工业] O63[理学—高分子化学]