氧化还原/pH双重响应性海藻酸钠/聚多巴胺纳米凝胶的制备及抗肿瘤研究  

Preparation and Anti-tumor Studies of Redox/pH Dual Responsive Alginate/Polydopamine Nanogels

作　　者：杨园园 吴思琦 李博 张玉红[1] YANG Yuan-yuan;WU Si-qi;LI Bo;ZHANG Yu-hong(Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry,Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials,College of Chemistry and Chemical Engineering,Hubei University,Wuhan 430062)

机构地区：[1]有机化工新材料省部共建协同创新中心,功能材料绿色制备与应用教育部重点实验室,湖北大学化学化工学院,武汉430062

出　　处：《胶体与聚合物》2022年第2期92-96,共5页Chinese Journal of Colloid & Polymer

摘　　要：通过溶液氧化法合成聚多巴胺纳米粒子(PDA NPs),用甘氨酸以羧基修饰,得到羧基化聚多巴胺纳米粒子(PDG),通过双乳液法,将海藻酸钠(SA)和PDG在胱胺作用下交联成杂化纳米凝胶(PDGS)。PDGS纳米凝胶能在24h还原性环境中有效降解,装载药物后载药纳米凝胶可在微酸性和还原性肿瘤微环境下实现响应性释放。Polydopamine nanoparticles(PDA NPs) were synthesized by solution oxidation method.Subsequently, carboxylated polydopamine nanoparticles(PDG) were obtained by modifying glycine with carboxyl groups of PDA. Sodium alginate(SA) and PDG were cross-linked into hybrid nanogels(PDGS) by double emulsion method under the action of cystamine. PDGS nanogels can be effectively degraded in a 24h reducing environment. After loading drugs, drug-loaded nanogels can achieve responsive release in a weakly acidic and reducing tumor microenvironment.

关 键 词：海藻酸钠 胱胺 双重乳液法 纳米凝胶 还原降解 

分 类 号：O63[理学—高分子化学]