某院ICU 116例新生患儿肛拭子标本中多重耐药菌的筛查与耐药情况分析  

Analysis of Screening and Drug Resistance of Multi-drug Resistant Bacteria in Anal Swab Specimens of 116 Newborns in ICU of a Hospital

作　　者：闫丽梅 YAN Li-mei(Laboratory Department of Shangqiu Maternal and Child Health Hospital,Shangqiu Henan 476000,China)

机构地区：[1]商丘市妇幼保健院检验科,河南商丘476000

出　　处：《抗感染药学》2022年第3期338-340,共3页Anti-infection Pharmacy

摘　　要：目的:分析医院ICU新生患儿肛拭子标本中多重耐药菌的筛查与耐药情况。方法:选取2018年3月—2020年11月商丘市妇幼保健院ICU收治的116例新生患儿作为研究对象,分析患儿肛拭子标本分离出的多重耐药菌的种类和耐药特点。结果:116例新生患儿的肛拭子标本中分离出多重耐药菌25株,其中主要为产超广谱β-内酰胺酶肠杆菌科细菌(extended-spectrum beta-lactamase-producing Enterobacterales,ESBLs-E)13株(占52.00%)、耐万古霉素肠球菌(vancomycin-resistant Enterococci,VRE)10株(占40.00%);ESBLs-E对亚胺培南、氨苄西林-舒巴坦钠、头孢西丁的耐药率均为0.00%;VRE对利奈唑胺、替考拉宁的耐药率均为0.00%。结论:医院ICU新生患儿多重耐药菌的感染情况较为严峻,感染的多重耐药菌以ESBLs-E和VRE为主,临床应加强对多重耐药菌的监测,根据病原菌的耐药特点合理选用抗菌药物,以保证治疗的效果。Objective:To analyze screening and drug resistance of multi-drug resistant bacteria in anal swab specimens of newborns in ICU of a hospital.Methods:116 newborns admitted to ICU of Shangqiu Maternal and Child Health Hospital from March 2018 to November 2020 were selected as research subjects,and the species and drug resistance characteristics of multi-drug resistant bacteria isolated from the anal swab specimens of the children were analyzed.Results:25 strains of multi-drug resistant bacteria were isolated from anal swab specimens of 116 newborns,mainly including 13 extended-spectrum beta-lactamase-producing Enterobacterales(ESBLs-E)(52.00%)and 10 vancomycin-resistant Enterococci(VRE)(40.00%).The drug resistance rates of ESBLs-E to imipenem,ampicillinsulbactam sodium and cefoxitin were 0.00%;the drug resistance rates of VRE to linezolid and teicoplanin were 0.00%.Conclusion:The newborns in ICU of the hospital are seriously affected by multi-drug resistant bacteria,and the infected multi-drug resistant bacteria are mainly ESBLs-E and VRE.Clinically,the monitoring on multi-drug resistant bacteria should be enhanced,and antibacterial drugs should be reasonably selected according to the drug resistance characteristics of pathogenic bacteria to ensure the treatment effect.

关 键 词：新生儿 ICU 多重耐药菌 耐万古霉素肠球菌 产超广谱β-内酰胺酶肠杆菌科细菌 

分 类 号：R915[医药卫生—微生物与生化药学] R969.3[医药卫生—药学]