药物所致卵巢发育毒性及机制的研究进展  

Advances in research on drug-induced ovarian developmental toxicity and mechanism

作　　者：黄晶 陈雅文[2] 柳毅 吕丰 汪晖 HUANG Jing;CHEN Ya-wen;LIU Yi;LYU Feng;WANG Hui(Dept of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;Dept of Pharmacology, Basic Medicine School of Wuhan University, Hubei Provincial Key Laboratory of Development Originated Diseases, Wuhan 430071, China;Dept of Pharmacy, People′s Hospital of Wuhan University, Wuhan 430060, China)

机构地区：[1]武汉大学中南医院妇产科,湖北武汉430071 [2]武汉大学基础医学院药理学系,发育源性疾病湖北省重点实验室,湖北武汉430071 [3]武汉大学人民医院药剂科,湖北武汉430060

出　　处：《中国药理学通报》2022年第7期970-974,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金青年科学基金资助项目(No 81903729)。

摘　　要：孕期药物(如内分泌及神经系统药物)使用不当可致雌性胎儿卵巢发育毒性,并造成出生后卵巢早衰等相关疾病易感。其发生机制主要涉及表观遗传修饰异常、氧化应激损伤、宫内神经内分泌发育编程等。该文系统综述了孕期用药导致的子代卵巢发育毒性及其宫内编程机制,为预防及控制卵巢相关疾病提供依据。Improper use of drugs during pregnancy(such as endocrine and nervous system drugs)can cause fetal ovarian developmental toxicity,which induces premature ovarian failure and other related diseases susceptible in adulthood.The mechanism of ovarian developmental toxicity mainly involves abnormal epigenetic modification during fetal period,oxidative stress injury,intrauterine neuroendocrine development programming,etc.In this paper,the ovarian developmental toxicity and intrauterine programming mechanism of offspring induced by pregnancy medication are systematically reviewed to provide evidence for the prevention and control of ovary-related diseases.

关 键 词：孕期 药物 卵巢发育毒性 表观遗传修饰 氧化应激损伤 神经内分泌发育编程 

分 类 号：R322.65[医药卫生—人体解剖和组织胚胎学] R339.22[医药卫生—基础医学] R394R711.75R977.1