丹参酮在阿尔茨海默病中的神经保护作用机制研究进展  

Recent progress on neuroprotective mechanisms of tanshinone in Alzheimer′s disease

作　　者：张志华 王洪权 李强 ZHANG Zhi-hua;WANG Hong-quan;LI Qiang(Dept of Neurology, The Affiliated Hospital of Chifeng University, Chifeng, Inner Mongolia 024005, China;Dept of Neurology & Aerospace Medical Center, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, China)

机构地区：[1]赤峰学院附属医院神经内科,内蒙古赤峰024005 [2]航天中心医院、北京大学航天临床医学院神经内科/航天医学中心,北京100049

出　　处：《中国药理学通报》2022年第7期983-986,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81260196,81450036);内蒙古自治区高等学校青年科技英才支持计划(No NJYT-17-B23);内蒙古自然科学基金资助项目(No 2018MS08046,2020MS08175,2021MS08131);内蒙古自治区高校科研项目(No NJZY19218);航天医科科研基金资助项目(No 2020YK02)。

摘　　要：丹参酮(tanshinone)是从丹参根茎中分离得到的一种亲脂性二萜类化合物,对多种疾病具有药理活性。近年来,丹参酮因其对阿尔茨海默病(Alzheimer′s disease,AD)实验模型的神经保护作用而成为研究最广泛的植物化学药物之一。近年研究显示,丹参酮可抑制胆碱酯酶活性、调控beta-淀粉样蛋白生成和聚集、调控tau蛋白磷酸化和抗炎作用,而在AD中发挥神经保护作用,因此,该文对以丹参酮IIA为代表的丹参酮在AD中的运用基础研究及其可能的神经保护作用及其机制进展进行了总结和归纳,以期对后续研究起指导作用。Aim Tanshinones,lipophilic diterpenes isolated from the rhizome of Salvia miltiorrhiza,have diverse pharmacological activities against Alzheimer′s disease(AD).Recently tanshinones have been the most widely studied phytochemicals for their neuroprotective effects against experimental models of AD.Recent studies have shown that tanshinones can inhibit cholinesterase activity,regulate generation and aggregation of beta-amyloid,regulate tau phosphorylation and exert anti-inflammatory effects,thereby playing a neuroprotective role in AD.The present study aims at reviewing experimental studies and describing the possible underlying molecular mechanisms by which tanshinones and releated compounds protect against AD.

关 键 词：阿尔茨海默病 丹参酮 丹参酮IIA 神经保护 神经炎症 beta淀粉样蛋白 

分 类 号：R282.71[医药卫生—中药学] R284.1[医药卫生—中医学] R745.7