四川牦牛心包与澳洲黄牛心包对比研究  

Comparative study on Sichuan yak pericardium and Australian cattle pericardium

作　　者：左一聪 康珂[2] 尚大鹏 杨夏燕 吴尧[4] 虞奇峰 温贤涛 ZUO Yicong;KANG Ke;SHANG Dapeng;YANG Xiayan;WU Yao;YU Qifeng;WEN Xiantao(Chengdu NewMed Biotechnology Co.,Ltd,Chengdu 611139,P.R.China;Institute of Regulatory Science for Medical Device/College of Biomedical Engineering,Sichuan University,Chengdu 610065,P.R.China;Shanghai NewMed Medical Co.,Ltd,Shanghai 201321,P.R.China;National Engineering Research Center for Biomaterials/College of Biomedical Engineering,Sichuan University,Chengdu 610064,P.R.China)

机构地区：[1]成都纽脉生物科技有限公司,成都611139 [2]四川大学生物医学工程学院/医疗器械监管科学研究院,成都610065 [3]上海纽脉医疗科技股份有限公司,上海201321 [4]四川大学生物医学工程学院/国家生物医学材料工程技术研究中心,成都610064

出　　处：《生物医学工程学杂志》2022年第3期537-543,共7页Journal of Biomedical Engineering

基　　金：浦东区科技发展基金(PKX2019-S14)。

摘　　要：牛心包作为人工心脏生物瓣关键原材料目前基本依靠进口,已然成为“卡脖子”难题,严重限制了国产生物瓣研发效率,因此牛心包国产化迫在眉睫。本文以四川牦牛心包为样本,在基础性能及抗钙化性能方面与澳洲黄牛心包进行了对比研究,结果表明牦牛心包在外观及厚度方面更优,热皱缩性能、力学性能及抗钙化性能不弱于澳洲心包。本研究初步验证了四川牦牛心包替代澳洲黄牛心包的可行性,为牛心包国产化的推进提供了有力的数据支撑。Currently, as the key raw material of artificial biological heart valve, bovine pericardium is mainly depend on import and has become a “bottleneck” challenge, greatly limiting the development of domestic biological heart valve. Therefore, the localization of bovine pericardium is extremely urgent. In this study, the pericardium of Sichuan yak was compared with that of Australian cattle in terms of fundamental properties and anti-calcification performance. The results demonstrated that the appearance and thickness of yak pericardium were more advantageous than the Australian one. Sichuan yak pericardium and Australian cattle pericardium had comparable performance in shrinkage temperature, mechanical test and anti-calcification test. This study preliminarily verifies the feasibility of substitution of Australian cattle pericardium by Sichuan yak pericardium and promotes the progression of bovine pericardium localization with data support.

关 键 词：四川牦牛心包 澳洲黄牛心包 基础性能 抗钙化性能 

分 类 号：R318.08[医药卫生—生物医学工程]