三维生物打印技术在泌尿系组织工程中的研究进展  

Research advances of three-dimensional bioprinting technology in urinary system tissue engineering

作　　者：符舟洋 肖树伟(综述) 符伟军(审校)[2] FU Zhouyang;XIAO Shuwei;FU Weijun(Chinese PLA Medical School,Beijing 100853,P.R.China;Department of Urology,the Third Medical Center,Chinese PLA General Hospital,Beijing 100039,P.R.China)

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院第三医学中心泌尿外科医学部,北京100039

出　　处：《生物医学工程学杂志》2022年第3期639-644,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金(81873600);北京市自然科学基金(7182154);海南省重点研发计划社会发展专项课题(ZDYF2016119);海南省自然科学基金(20158299);海南省医药卫生重点科研项目(14A110062);教育部留学回国人员科研启动基金。

摘　　要：针对泌尿系疾病导致的组织器官损伤和缺失,目前临床上的治疗方法存在局限性。组织工程通过对细胞、生物支架和生物相关分子的研究,提供了一种可替代或再生受损组织器官的治疗手段。三维(3D)生物打印技术作为新兴制造技术,能对载有细胞的生物材料精确控制,进一步推动着组织工程领域的发展。本文综述了3D生物打印技术在肾脏、输尿管、膀胱、尿道组织工程中的研究进展和应用,并讨论了目前面临的主要挑战和未来展望。For the damage and loss of tissues and organs caused by urinary system diseases, the current clinical treatment methods have limitations. Tissue engineering provides a therapeutic method that can replace or regenerate damaged tissues and organs through the research of cells, biological scaffolds and biologically related molecules. As an emerging manufacturing technology, three-dimensional(3D) bioprinting technology can accurately control the biological materials carrying cells, which further promotes the development of tissue engineering. This article reviews the research progress and application of 3D bioprinting technology in tissue engineering of kidney, ureter, bladder, and urethra.Finally, the main current challenges and future prospects are discussed.

关 键 词：三维生物打印技术 组织工程 泌尿外科 生物材料 

分 类 号：R318.08[医药卫生—生物医学工程] R699[医药卫生—基础医学]