血清清蛋白、中性粒细胞/淋巴细胞比值与慢性阻塞性肺疾病急性加重的相关性研究  

The relationship between serum albumin,neutrophil/lymphocyte ratio and acute exacerbation of COPD

作　　者：刘秀凤[1] 周婷[1] 范琳漪 张晔[1] LIU Xiufeng;ZHOU Ting;FAN Linyi;ZHANG Ye(South Campus of the Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 201499,China;Shanghai Medical College of Health,Shanghai 201318,China)

机构地区：[1]上海交通大学附属第六人民医院南院,上海201499 [2]上海健康医学院,上海201318

出　　处：《国际检验医学杂志》2022年第S01期55-59,共5页International Journal of Laboratory Medicine

摘　　要：目的 探讨血清清蛋白(ALB)、中性粒细胞/淋巴细胞比值(NLR)与慢性阻塞性肺疾病急性加重(AECOPD)的相关性研究。方法 选取55例慢性阻塞性肺疾病急性加重住院患者(AECOPD组)、55例慢性阻塞性肺疾病稳定期患者(COPD组)、55例同期体检健康者(健康对照组),比较3组ALB、总蛋白(TP)、超敏C反应蛋白(CRP)、白细胞(WBC)、中性粒细胞(NC)、淋巴细胞(LC)、NLR水平;将AECOPD患者的肺功能按照慢性阻塞性肺疾病全球倡议(GOLD)分级分为COPD急性加重期组和COPD稳定期组,同时根据ALB水平,分为营养良好组、营养不良组,分析AECOPD肺功能分级与ALB、TP和NLR的相关性。结果 COPD急性加重期患者ALB、TP和LC水平均低于COPD稳定期患者及健康对照组;WBC、NC和NLR水平均高于COPD稳定期患者及健康对照组,差异均有统计学意义(均P<0.05);AECOPD营养不良组患者CRP>10(mg/L)的比率高于AECOPD营养良好组患者,差异有统计学意义(P<0.05);AECOPD营养不良组患者TP水平明显低于AECOPD营养良好组患者,差异有统计学意义(P<0.05);AECOPD营养不良组患者年龄大于AECOPD营养良好组患者,差异有统计学意义(P<0.05);肺功能GOLD 3~4级患者NLR值高于GOLD 1~2级患者,差异有统计学意义(P<0.05);GOLD 3~4级患者WBC水平高于GOLD 1~2级患者且ALB水平略低于GOLD 1~2级患者,差异均有统计学意义(均P<0.05);吸烟组FEV1/FVC值与FEV1值水平均明显高于非吸烟者,差异有统计学意义(P<0.05)。结论 ALB及NLR和慢性阻塞性肺疾病急性加重具有相关性,可以评估AECOPD的严重程度及预后,对临床诊断和治疗具有重要指导意义。Objective To investigate the correlation between serum albumin(ALB),neutrophil/lymphocyte ratio(NLR)and acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Fifty-five hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD group),55 patients with stable stage of chronic obstructive pulmonary disease(COPD group)and 55 healthy people at the same period(healthy control group)were selected.ALB,TP,CRP,WBC,NC and LC were compared among the three groups According to the global initiative for chronic obstructive pulmonary disease(gold),the pulmonary function of patients with AECOPD was divided into two groups.At the same time,according to the level of ALB,the patients were divided into the well nourished group and the malnourished group.The correlation between the pulmonary function of AECOPD and ALB,TP,NLR was analyzed.Results ALB and TP were found in COPD patients,LC level was lower than that of COPD stable patients and healthy control group;WBC,NC and NLR levels were higher than that of COPD stable patients and healthy control group,the differences were statistically significant(all P<0.05);CRP>10(mg/L)rate of patients with AECOPD malnutrition was higher than that of patients with AECOPD malnutrition,the difference was statistically significant(P<0.05);TP level of patients with AECOPD malnutrition was significantly lower than that of patients with AECOPD malnutrition,the difference was statistically significant(P<0.05);AECOPD malnutrition The age of patients in group A was older than that in group A,the difference was statistically significant(P<0.05);the NLR value of patients in group B was significantly higher than that in group B(P<0.05);the WBC level of patients in group B was slightly lower than that in group B,the differences were statistically significant(all P<0.05);the FEV1/FVC value and FEV1 value in group B were significantly higher than those in group B,the difference was statistically significant(P<0.05).Conclusion ALB and NLR are correlated wi

关 键 词：血清清蛋白 中性粒细胞 淋巴细胞 慢性阻塞性肺疾病 

分 类 号：R56[医药卫生—呼吸系统]