2016-2019年广州地区孕妇梅毒血清学检测结果分析  

Analysis on syphilis infection of pregnant women in Guangzhou from 2016 to 2019

作　　者：叶青[1] 郑冼华[1] 刘艳[1] 赖有行[1] YE Qing;ZHENG Xianhua;LIU Yan;LAI Youxing(Department of Clinical Laboratory,Guangdong Maternal and Child Health Hospital,Guangzhou,Guangdong 510010,China)

机构地区：[1]广东省妇幼保健院检验科,广东广州510010

出　　处：《国际检验医学杂志》2022年第S01期65-68,共4页International Journal of Laboratory Medicine

摘　　要：目的 分析产科门诊常规产检孕妇梅毒血清学检测结果,了解孕妇人群梅毒感染状况,为围生期管理和预防梅毒母婴传播提供参考。方法 回顾性分析产科门诊常规产检孕妇首次进行血清梅毒螺旋体抗体(TPPA)检测和非梅毒螺旋体抗体(TRUST)检测的实验室结果,对不同年份组、不同年龄组以及不同孕期组孕妇梅毒感染状况进行分析。结果 2016-2019年共计35682例孕妇进行了梅毒血清血检测,检测结果为梅毒螺旋体明胶凝集试验TPPA(+)并且TRUST(+)的梅毒感染孕妇总共158例,阳性率为4.43‰。2016-2019年孕妇梅毒感染阳性率依次为5.91‰、4.38‰、3.25‰、4.43‰;不同年龄组孕妇(≤25岁组、26~30岁组、31~35岁组、≥36岁组)梅毒感染阳性率比较差异有统计学意义(χ^(2)=33.05,P<0.05),≥36岁组孕妇梅毒感染阳性率最高9.06‰;26~30岁组孕妇梅毒感染阳性率最低2.66‰;不同孕期组孕妇(孕早期组、孕中期组、孕晚期组)梅毒感染阳性率比较差异有统计学意义(χ^(2)=19.02,P<0.05),孕早期组孕妇梅毒感染阳性率最高7.59‰。结论 广州地区孕妇梅毒感染阳性率仍处于相对较高水平,提示为了更好的预防梅毒母婴传播需要加强对育龄妇女的孕前宣教、早期筛查、规范治疗和定期随访。Objective To investigate the syphilis infection status of pregnant women in the obstetric out-patient department in Guangzhou from 2016 to 2019,and to provide reference for intervention and prevention of mother-to-child transmission of syphilis in perinatal period.Methods Retrospectively analyzed the laboratory results of the serum TPPA and TRUST testing taken for pregnant women in the obstetric out-patient department between January,2016 and December,2019.Analyzed the syphilis infection status in pregnant women by different years(2016,2017,2018,2019),ages(≤25,26-30,31-35,≥36)and gestation periods(early pregnancy,mid-pregnancy and late pregnancy).Results A total of 35,682 pregnant women were involved in the analysis,158 out of them were syphilis-seropositive with both TPPA(+)and TRUST(+),the positive rate was 4.43‰(158/35682).Divided by different years,the positive rates were 5.91‰(45/7614),4.38‰(41/9362),3.25‰(30/9225)and 4.43‰(42/9481)from 2016 to 2019.The difference of the positive rates from different age groups was statistically significant(χ^(2)=33.05,P<0.05).The positive rate was the highest(9.06‰,34/3750)at age over 36 years old;the positive rate of those aged 26-30 years was the lowest(2.66‰,39/14637).The difference of the positive rates in different gestation periods was also statistically significant(χ^(2)=19.02,P<0.05),the early pregnancy group had the highest positive rate(7.59‰,51/6713).Conclusion The prevalence of syphilis infection in pregnant women in Guangzhou is at a relatively high level.Serological screening of syphilis in pregnant women is effective to reduce the incidence of congenital syphilis and prevent the vertical transmission of syphilis to the infants.

关 键 词：梅毒 孕妇 血清学检测 

分 类 号：R75[医药卫生—皮肤病学与性病学]