南宁地区性病门诊患者支原体感染及耐药趋势分析  

Analysis of mycoplasma infection and drug resistance trends among patients in sexually transmitted diseases clinics in Nanning

作　　者：韦江平 朱邦勇 李伟 黄寅杰 韦晓宁 WEI Jiangping;ZHU Bangyong;LI Wei;HUANG Yinjie;WEI Xiaoning(Department of Clinical Laboratory,Guangxi Institute of Dermatology,Nanning,Guangxi 530003,China;Department of Obstetrics and Gynecology,the First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530021,China)

机构地区：[1]广西壮族自治区皮肤病防治研究所检验科,广西南宁530007 [2]广西医科大学第一附属医院妇产科,广西南宁530021

出　　处：《国际检验医学杂志》2022年第S01期81-85,共5页International Journal of Laboratory Medicine

摘　　要：目的 了解解脲支原体(Uu)和人型支原体(Mh)对抗菌药物耐药情况,为临床选药治疗支原体感染提供参考。方法 收集广西壮族自治区皮肤病防治研究所(下称本院)2014年7月到2020年11月性病门诊泌尿生殖道感染7567例疑诊患者支原体感染12种抗菌药物的药敏结果。结果 1384例(18.29%)患者支原体阳性,其中Uu感染1257例(16.59%),Mh感染562例(7.4%),混合感染418例(5.53%)。Uu灵敏度最高的为交沙霉素(95.26%)、环脂红霉素(93.09%)、克拉霉素(92.57%)和美满霉素(91.42%);Mh敏感度最强的是交沙霉素(95.12%)、多西环素(93.50%)以及美满霉素(91.06%)。7年来,耐药最严重的为环丙沙星及左氧氟沙星,两者耐药率比较差异无统计学意义(P>0.05);而多西环素、交沙霉素、甲砜霉素、美满霉素和阿奇霉素耐药率逐年有下降的趋势,差异具有统计学意义(P<0.05)。结论 本院支原体治疗首选交沙霉素、环脂红霉素、克拉霉素、美满霉素以及多西环素;建议暂停使用红霉素、环丙沙星和左氧氟沙星。Objective To analyze Ureaplasma urealyticum(Uu)or Mycoplasma hominis(Mh)infections of urogenital tract and resistance trends in sexually transmitted disease(STD)outpatients,to provide a new reference for drug administration in the clinic.Methods Seven thousand five hundred and sixty-seven cases of clinical doubtful patients of STD outpatient were enrolled from July 2014 to November 2020.Uu and Mh were detected and drug sensitivity tests were performed.Results One thousand three hundred and eighty-fourpatients were Mycoplasma positive,including 1257 cases of Uu infection(16.59%),562 cases of Mh(7.4%)infection,and 418 cases of mixed(Uu+Mh)infection.Uu showed high sensitivity to josamycine(95.26%),erythromycin cyclophosphate(93.09%),clarithromycin(92.57%),and minocycline(91.42%);Mh showed high sensitivity to josamycine(95.12%),doxycycline(93.50%),and minocycline(91.06%).The drug resistance rates of ciprofloxacin and levofloxacin did not change significantly(P>0.05)in the past 7 years;while the drug resistance rates of doxycycline,josamycin,thiamphenicol,minocycline,and azithromycin decreased with statistical significance(P<0.05).Conclusion Josamycine,erythromycin cyclophosphate,clarithromycin,minocycline,and doxycycline can be used as the first choice in Mycoplasma treatment,while erythromycin,ciprofloxacin,and levofloxacin should be suspended.

关 键 词：支原体 泌尿生殖道 药敏 

分 类 号：R44[医药卫生—诊断学]