2型糖尿病患者CYFRA21-1异常的原因分析  

Analysis of causes of abnormal CYFRA21-1 in patients with type 2 diabetes

作　　者：陈建栋[1] 陈建中[1] 孟伟[1] CHEN Jiandong;CHEN Jianzhong;MENG wei(Department of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院检验科,上海201203

出　　处：《国际检验医学杂志》2022年第S01期100-103,共4页International Journal of Laboratory Medicine

摘　　要：目的 探讨2型糖尿病(T2DM)患者血清中细胞角蛋白19片段抗原21-1(CYFRA21-1)异常升高的原因。方法 收集164例T2DM患者为患者组,根据CYFRA21-1水平将T2DM患者分为两组,即CYFRA21-1水平正常组(81例)和CYFRA21-1水平升高组(83例)。另以78例健康体检者作为健康组。分别检测CYFRA21-1水平,并收集空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血清蛋白(ALB)、肌酐(Cr)、尿微量清蛋白(UAlb)、糖尿病病程等数据进行分析。结果 CYFRA21-1、FPG、HbA1c、TG、HDL-C、血ALB、UAlb、体质量指着(BMI)在3组间差异均有统计学意义(P<0.05)。CYFRA21-1水平与FPG、HbA1c、LDL-C、HDL-C、血ALB、Cr、UAlb、病程均有相关性(P<0.05)。多元回归分析显示FPG、HbA1c、HDL-C、LDL-C是CYFRA21-1升高的危险因素(P<0.05)。结论 T2DM患者血清CYFRA21-1升高与多种因素有关,临床上应结合血糖、糖化血红蛋白、血脂水平综合考虑,以免误诊。Objective To explore the cause of abnormal increase of serum cytokeratin 19 fragment antigen 21-1(CYFRA21-1)in patients with type 2 diabetes(T2DM).Methods One hundred and sixty-four T2DM patients were selected as the patient group.According to the level of CYFRA21-1,T2DM patients were divided into two groups:the normal CYFRA21-1 level group(n=81)and the elevated CYFRA21-1 level group(n=83).In addition,78 healthy people were enrolled as the normal group.CYFRA21-1,fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),blood albumin(ALB),creatinine(Cr),urinary microalbumin(UAlb)were detected.Information on duration of diabetes were also collected.Results There were significant differences in CYFRA21-1,FPG,HbA1c,TG,HDL-C,blood ALB,UAlb and BMI among the three groups,the difference was statistically significant(P<0.05).CYFRA21-1 was correlated with FPG,HbA1c,LDL-C,HDL-C,ALB,Cr,UAlb,and diabetes duration,the difference was statistically significant(P<0.05).Meanwhile,multinomial regression analysis showed that FPG,HbA1c,HDL-C and LDL-C were the risk factors for the increase of CYFRA21-1,the difference was statistically significant(P<0.05).Conclusion The abnormal increase of serum CYFRA21-1 in T2DM patients is related to many factors.In clinical practice,it should be considered in combination with the levels of blood glucose,HbA1c and blood lipids to avoid misdiagnosis.

关 键 词：2型糖尿病 细胞角蛋白19片段 原因分析 

分 类 号：R58[医药卫生—内分泌]