伊维菌素乳膏联合窄谱强脉冲光治疗玫瑰痤疮临床疗效观察  

The Clinical Effect of Ivermectin Cream Combined with Narrow-spectrum Intense Pulse Light on Rosacea

作　　者：王娜 董文馨 袁肖海 WANG Na;DONG Wenxin;YUAN Xiaohai(Department of Medical Cosmetology,Shanghai Skin Disease Hospital,Shanghai 200443,China)

机构地区：[1]上海市皮肤病医院医学美容科,上海200443

出　　处：《中国美容医学》2022年第6期24-27,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探究伊维菌素乳膏联合窄谱强脉冲光治疗玫瑰痤疮的临床疗效及对IGA评分的影响。方法:选取2017年3月-2019年9月入笔者医院的75例玫瑰痤疮患者,随机分为对照组37例,采用伊维菌素乳膏外用治疗;研究组38例,采用伊维菌素乳膏联合窄谱强脉冲光治疗。观察两组的临床疗效与总体评分IGA(Investigator’s global assessment)、VISIA面部红区数值、临床症状积分,记录患者的不良反应。结果:治疗后,研究组的总有效率为92.11%明显高于对照组的72.97%(P<0.05);两组患者的总体评分IGA明显下降,且研究组明显低于对照组(P<0.05);两组面部红区数值均明显改善,且研究组优于对照组(P<0.05)。治疗前两组患者的红斑、丘疹脓疱、瘙痒等症状积分无统计学差异(P>0.05),治疗后两组患者的各症状积分明显下调,且研究组低于对照组(P<0.05);两组的不良反应发生率比较无统计学差异(P>0.05)。结论:采用联合方式治疗玫瑰痤疮的疗效优于单独使用伊维菌素乳膏,且安全性高,提供更佳的治疗策略。Objective To explore the clinical efficacy of ivermectin cream combined with narrow-spectrum intense pulselight in the treatment of rose acne at different stages and its influence on IGA score.Methods A total of 75 rosacea patients who were admitted to author hospital from March 2017 to September 2019 were selected and randomly divided into 37 cases in the control group,treated with ivermectin cream for patients with type I and type II rosacea,38 cases in the study group were treated with ivermectin cream combined with narrow-spectrum intense pulsed light.The clinical efficacy and overall score of IGA(Investigator’s Global Assessment),the score of VISIA facial red areas,the symptom score before and after treatment,record the patient’s adverse reactions.Results The total effective rate of the study group was 92.11%(35/38),which was significantly higher than the control group’s 72.97%(P<0.05).The overall IGA score of the two groups of patients decreased significantly,and the study group was significantly lower than the control group(P<0.05).The score of facial red areas were significantly improved in both groups,and the study group was better than the control group(P<0.05).There was no statistical difference in the scores of symptoms such as erythema,papules,pustules,and itching between the two groups before treatment(P>0.05).After treatment,the symptom scores of the two groups of patients improved significantly,and the study group was lower than the control group(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion The curative effect of combined treatment was better than that of ivermectin cream alone,and it was safe and provided a more optimized treatment strategy.

关 键 词：伊维菌素乳膏 窄谱强脉冲光 玫瑰痤疮 IGA评分 临床疗效 

分 类 号：R758.734[医药卫生—皮肤病学与性病学]