中性粒细胞HDC/histamine信号:抗血栓治疗的新靶点  

Targeting histamine/HR signal in HDC-expressing neutrophils to prevent thrombosis

作　　者：杨茜洋 肖纯[2] 杨向东[1,2] YANG Xiyang;XIAO Chun;YANG Xiangdong(Institute of Cardiovascular Disease,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Center of Cardiovascular Medicine,the Third People's Hospital of Huizhou,Huizhou,Guangdong 516003,China)

机构地区：[1]复旦大学附属中山医院心血管研究所,上海市200032 [2]惠州市第三人民医院心血管医学中心,广东省惠州市516003

出　　处：《中国动脉硬化杂志》2022年第7期568-574,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(82170258);上海市科委基础研究项目(19JC1411400);实验动物项目(19140902000、201409005000)。

摘　　要：血栓及其并发症是一种危害健康的临床病症。中性粒细胞胞外诱捕网(NET)是由中性粒细胞释放、解聚的染色质形成的细胞外的纤维网络,通过激活血小板、加速凝血从而促进血栓形成影响疾病转归。组氨酸脱羧酶(HDC)是催化组胺(histamine)生成的关键酶,在中性粒细胞,尤其是骨髓内不成熟CD11b+髓系细胞内有高水平表达。组胺信号参与过敏反应、胃酸分泌、炎症、免疫反应和肿瘤发生等多种生理和病理生理事件。组胺及其下游相关信号对中性粒细胞极化、NET形成和血栓发生发展的调控,可能成为血栓性疾病靶向药物研发的重要参考。文章主要对表达HDC的中性粒细胞在血栓形成和发生发展的作用进行综述。Thrombosis and its complications are a clinical condition that endangers health.Neutrophil extracellular trap networks(NET)are extracellular fibrous networks formed by neutrophil-released,depolymerized chromatin that influence disease regression by activating platelets,accelerating clotting and thus promoting thrombosis.Histidine decarboxylase(HDC),a key enzyme catalyzing histamine production,is highly expressed in neutrophils,particular in the bone marrow-derived immature myeloid cells.Histamine signaling is involved in allergic reactions,gastric acid secretion,inflammation,immune responses,and tumorigenesis in relation to a variety of physiological and pathophysiological events.Targeting HDC-expressing neutrophils and the regulation of histamine related downstream signal on neutrophil differentiation,NET formation and thrombogenesis development might become a new antithrombotic strategy.This article mainly reviews the role of HDC-expression neutrophils inthrombosis.

关 键 词：中性粒细胞 中性粒细胞胞外诱捕网 血栓 动脉粥样硬化 缺血性心脏病 

分 类 号：R5[医药卫生—内科学]