体质指数与腹主动脉钙化的患病率呈负相关  

Body mass index was inversely associated with the prevalence of abdominal aortic calcification

作　　者：俞婷婷[1] 吴韩[2] 王昆[2] YU Tingting;WU Han;WANG Kun(Department of Geriatrics,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing,Jiangsu 210008,China;Department of Cardiology,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing,Jiangsu 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院老年科,江苏省南京市210008 [2]南京大学医学院附属鼓楼医院心内科,江苏省南京市210008

出　　处：《中国动脉硬化杂志》2022年第8期676-680,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81970296)。

摘　　要：[目的]探讨体质指数(BMI)或肥胖是否与腹主动脉钙化(AAC)的患病率有关。[方法]从2013年—2014年美国国家健康和营养检查调查(NHANES)数据中提取了3116名年龄大于18岁的参与者。AAC是基于双能X射线吸收法(DXA)测定定义的。Logistic回归分析BMI或肥胖与AAC之间的相关性。森林图说明了亚组之间调整后的优势比(OR)。采用限制性立方样条回归探索潜在的非线性关系。[结果]调整混杂因素后,BMI仍与AAC的患病率呈负相关(OR=0.89,95%CI为0.81~0.98,P=0.013);与正常BMI相比,肥胖防止AAC的可能性更大(OR=0.38,95%CI为0.16~0.94,P=0.037)。该关联在男性(OR=0.82,95%CI为0.69~0.96)、年龄>60岁(OR=0.89,95%CI为0.80~0.99)、无高血压(OR=0.76,95%CI为0.62~0.93)、无糖尿病(OR=0.87,95%CI为0.78~0.97)的亚组中仍然显著。限制性立方样条回归揭示了BMI和AAC之间的非线性关系(P=0.0023)。[结论]BMI与AAC的患病率呈负相关,可能是AAC的一个新预测指标。Aim To investigate whether body mass index(BMI)or obesity is associated with the prevalence of abdominal aortic calcification(AAC).Methods 3116 participants older than 18 were extracted from the data of the National Health and Nutrition Examination Survey(NHANES)from 2013 to 2014.AAC was defined based on dual-energy X-ray absorptiometry(DXA).Logistic regression was performed to analyze the association between BMI or obesity and AAC.The adjusted odds ratio(OR)among subgroups was illustrated in the forest map.Restricted cubic spline regression was fitted to explore the potential nonlinear relationship.Results BMI was inversely associated with AAC even after adjusted for confounders(OR=0.89,95%CI was 0.81~0.98,P=0.013),and the obesity was more likely to prevent AAC than normal BMI(OR=0.38,95%CI was 0.16~0.94,P=0.037).The association was still significant in the subgroups of male(OR=0.82,95%CI was 0.69~0.96),age>60(OR=0.89,95%CI was 0.80~0.99),without hypertension(OR=0.76,95%CI was 0.62~0.93)and without diabetes(OR=0.87,95%CI was 0.78~0.97).Restricted cubic spline regression revealed a non-linear relationship between BMI and AAC(P=0.0023).Conclusion BMI was inversely associated with the prevalence of AAC,which could be a new predictor of AAC in the clinical practice.

关 键 词：体质指数 腹主动脉钙化 双能X射线吸收法 

分 类 号：R54[医药卫生—心血管疾病]