预测颈动脉粥样硬化易损斑块的新型生物标志物研究进展  

Research progress of novel biomarkers for predicting vulnerable plaque in carotidatherosclerosis

作　　者：李梦馨 庞萌 李健[2] 耿建红[2] 王炎强[2] LI Mengxin;PANG Meng;LI Jian;GENG Jianhong;WANG Yanqiang(Graduate School of Weifang Medical University,Weifang,Shandong 261031,China;Second Department of Neurology,Affiliated Hospital of Weifang Medical University,Weifang,Shandong 261031,China)

机构地区：[1]潍坊医学院研究生院,山东省潍坊市261031 [2]潍坊医学院附属医院神经内二科,山东省潍坊市261031

出　　处：《中国动脉硬化杂志》2022年第8期714-718,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81870943);山东省重点研发计划项目(2015GSF118146);山东省科技计划项目(202003070377)。

摘　　要：易损斑块是指动脉壁内稳定性差的斑块,其易破裂、脱落,导致原位血栓或多发微栓子形成。颈动脉粥样硬化易损斑块是缺血性脑卒中的主要致病机制,颈动脉斑块易损性增加脑缺血事件的发生。因此,早期鉴别易损斑块,对干预脑卒中高危因素、改善脑卒中预后具有重要意义。除各类影像技术外,循环生物标志物为识别颈动脉易损斑块提供了辅助手段。本综述回顾以往研究,讨论能够识别颈动脉易损斑块的新型生物标志物。Vulnerable plaque refers to the plaque with poor stability in the arterial wall,which is easy to rupture and fall off,leading to the formation of in situ thrombus or multiple microemboli.Carotid atherosclerotic vulnerable plaque is the main pathogenic mechanism of ischemic stroke,and carotid plaque vulnerability increases the occurrence of cerebral ischemic events.Therefore,early identification of vulnerable plaques is of great significance for intervening high-risk factors for stroke and improving stroke prognosis.In addition to various imaging techniques,circulating biomarkers provide an adjunct to the identification of vulnerable carotid plaques.This article reviews previous studies,discussing novel biomarkers capable of identifying carotid vulnerable plaques.

关 键 词：颈动脉粥样硬化 易损斑块 生物标志物 缺血性脑卒中 

分 类 号：R543.4[医药卫生—心血管疾病]