脂肪酸结合蛋白4在下肢动脉粥样硬化及介入术后再狭窄中的作用和机制  

Role and mechanism of fatty acid-binding protein 4 in lower extremity atherosclerosis and restenosis after interventional therapy

作　　者：谭崇赋 徐旭英[1] TAN Chongfu;XU Xuying(Department of Sore and Vascular Surgery,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院疮疡血管外科,北京市100010

出　　处：《中国动脉硬化杂志》2022年第8期725-730,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81673975、81873118)。

摘　　要：下肢动脉硬化闭塞症介入术后的主要难题是再狭窄。脂肪酸结合蛋白4(FABP4)主要由巨噬细胞分泌,促进巨噬细胞内脂质积聚,从而使巨噬细胞转化为泡沫细胞,造成动脉粥样硬化。在动脉粥样硬化闭塞介入术后,血管内皮细胞也能特异性分泌FABP4;FABP4作用于血管平滑肌细胞,使之增殖和迁移形成增生内膜,并促进炎症反应,造成介入术后再狭窄。提示FABP4可能是治疗动脉粥样硬化和介入术后再狭窄的一个重要靶点。本文简述FABP4的生物学特性与功能,并就其在动脉粥样硬化及介入术后再狭窄中的作用及机制进行综述。Restenosis is the main problem after interventional therapy in lower extremity arteriosclerosis obliterans.Fatty acid-binding protein 4(FABP4)is mainly secreted by macrophages and promotes lipid accumulation in macrophages,thereby converting macrophages into foam cells and causing atherosclerosis.After atherosclerotic occlusion interventional therapy,vascular endothelial cells can also specifically secrete FABP4;FABP4 acts on vascular smooth muscle cells,causing them to proliferate and migrate to form proliferative intima,and promote inflammatory response,resulting in restenosis after interventional therapy.It is suggested that FABP4 may be an important target for the treatment of atherosclerosis and restenosis after interventional therapy.This article briefly describes the biological characteristics and functions of FABP4,and reviews its role and mechanism in atherosclerosis and restenosis after interventional therapy.

关 键 词：脂肪酸结合蛋白4 动脉粥样硬化 动脉硬化闭塞症 介入术后再狭窄 

分 类 号：R543[医药卫生—心血管疾病]