致康胶囊对肛瘘术后伤口愈合及血清表皮生长因子、纤维连接蛋白表达的影响  

Effects of Zhikang Capsules on Wound Healing and Expression of Serum Epidermal Growth Factor,Fibronectin After Anal Fistula Surgery

作　　者：张东臣[1] 鲍虎豹 陆莎[1] 吴剑箫[1] 冯奇 ZHANG Dongchen;BAO Hubao;LU Sha;WU Jianxiao;FENG Qi(Dept.of Proctology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)

机构地区：[1]石家庄市中医院肛肠一科,石家庄050000

出　　处：《中国医院用药评价与分析》2022年第6期672-675,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省中医药管理局科研计划项目(No.2019442)。

摘　　要：目的:探讨致康胶囊对肛瘘术后伤口愈合及血清表皮生长因子(EGF)、纤维连接蛋白(FN)表达的影响。方法:纳入2019年3月至2020年7月该院肛肠科收治的肛瘘术后患者120例,采用随机数字表法分为对照组(n=60)和观察组(n=60)。在给予常规治疗的基础上,对照组患者给予高锰酸钾坐浴,观察组患者在对照组的基础上加服致康胶囊,共治疗14 d后评定疗效。比较两组患者创面渗液和水肿情况、创面肉芽形态、创面愈合率和愈合时间;分别于治疗前后检测各患者血清EGF和FN的表达水平;记录两组患者治疗期间的不良反应。结果:观察组患者的总有效率为93.33%(56/60),显著高于对照组(76.67%,46/60),差异有统计学意义(P<0.05)。对照组患者自用药后7 d开始,渗液和水肿积分显著低于用药前;而观察组患者自用药后3 d开始,渗液和水肿积分显著低于用药前;用药后3 d、7 d和14 d,观察组患者渗液和水肿积分均低于对照组,上述差异均有统计学意义(P<0.05)。自用药后3 d开始,两组患者的创面肉芽形态积分均显著低于用药前,且观察组患者的创面肉芽形态积分显著低于同一时间点的对照组,差异均有统计学意义(P<0.05)。与对照组相比,观察组患者创面愈合率较高、愈合时间较短,差异均有统计学意义(P<0.05)。用药14 d后,两组患者的EGF、FN的表达水平均较用药前显著升高;且与对照组相比,观察组患者EGF和FN表达水平升高较为显著,上述差异均有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应。结论:致康胶囊可显著提高肛瘘术后患者血清EGF和FN的表达,改善肛瘘术后伤口愈合,疗效确切可靠。OBJECTIVE:To probe into the effects of Zhikang capsules on wound healing and expression of serum epidermal growth factor(EGF),fibronectin(FN)after anal fistula surgery.METHODS:A total of 120 cases of postoperative anal fistula patients admitted into the proctology department of the hospital from Mar.2019 to Jul.2020 were extracted to be divided into the control group(n=60)and the observation group(n=60)via the random number table.On the basis of routine treatment,the control group was given fumigation of potassium permanganate,while the observation group received Zhikang capsules on the basis of the control group,and the curative effect was evaluated after 14 days of treatment.The effusion,edema,granulation morphology,healing rate and healing time of two groups were compared.The expression levels of EGF and FN were detected before and after treatment.Adverse drug reactions during treatment were recorded in two groups.RESULTS:The total effective rate in the observation group was 93.33%(56/60),significantly higher than 76.67%(46/60)in the control group,the difference was statistically significant(P<0.05).From the 7th day after treatment,the scores of effusion and edema in the control group were significantly lower than those before treatment;from the 3th day after treatment,the scores of effusion and edema in the observation group were significantly lower than those before treatment;at 3,7 and 14 days after treatment,the scores of effusion and edema in the observation group were lower than those in the control group,with statistically significant difference(P<0.05).From the 3th day after treatment,the wound granulation morphology scores of two groups were significantly lower than those before treatment,and the wound granulation morphology scores of the observation group were significantly lower than those of the control group at the same time point,with statistically significant difference(P<0.05).Compared with the control group,the wound healing rate was higher and the healing time was shorter in the observation g

关 键 词：致康胶囊 肛瘘 伤口愈合 表皮生长因子 纤维连接蛋白 

分 类 号：R932[医药卫生—生药学]