1例磺胺脱敏方案治疗干燥综合征合并卡氏肺孢子菌肺炎的药学监护  

One case of pharmaceutical care during sulfanilamide desensitization treatment of sjogren’s syndrome with pneumocystis carinii pneumonia

作　　者：刘蕾 张会娟 钱效森 孙瑞芳 LIU Lei;ZHANG Huijuan;QIAN Xiaosen;SUN Ruifang(Department of Pharmacy,Civil Aviation General Hospital,Beijing 100123,China;Department of Respiratory Medicine,Civil Aviation General Hospital,Beijing 100123,China)

机构地区：[1]民航总医院药剂科,北京100123 [2]民航总医院呼吸内科,北京100123

出　　处：《中国药物警戒》2022年第6期680-683,共4页Chinese Journal of Pharmacovigilance

基　　金：民航医学中心(民航总医院)科研基金资助项目(201927)。

摘　　要：目的探讨临床药师在干燥综合征合并卡氏肺孢子菌肺炎药物治疗中提供药学监护的方法和作用。方法临床药师参与1例干燥综合征合并卡氏肺孢子菌肺炎并有磺胺过敏史患者的药物治疗,面临替代药物不可获得或价格高昂时,建议临床采取磺胺脱敏方案治疗,并根据指南推荐用法设计了可行的磺胺脱敏试验实施步骤,与主治医师共同实施脱敏方案,同时对患者进行个体化的药学监护,从而保证疗效、避免药品不良反应发生。结果医师采纳临床药师建议,患者磺胺脱敏试验成功并顺利完成21 d治疗,患者肺内病灶基本吸收,感染得到控制。结论临床药师通过药学监护,优化患者的用药方案,及时帮助临床调整剂量,促进临床合理用药,提高了药物临床治疗的有效性和安全性,为患者节省了治疗费用。Objective To explore the role of clinical pharmacists in pharmaceutical care of a patient with Sjogren’s syndrome complicated with pneumocystis carinii pneumonia. Methods Clinical pharmacists participated in the treatment of a patient with Sjogren’s syndrome complicated with Pneumocystis carinii pneumonia. Due to the patient’s history of sulfanilamide allergy, the lack of alternative drugs and high cost, the pharmacists suggested trying the sulfanilamide desensitization test. According to the usage recommended by the guidelines, the feasible steps of the sulfanilamide desensitization test were designed, and the desensitization program was carried out with the attending physician. At the same time, individualized pharmaceutical care was provided to ensure the efficacy and to prevent adverse reactions.Results Physicians took the advice of clinical pharmacists and the sulfanilamide desensitization test was a success.After 21 days of treatment, the lung abnormal lesion was absorbed basically and infection was brought under control.Conclusion Clinical pharmacists can optimize the therapy plan of patients through pharmaceutical care to promote rational drug use in clinic, improve the effectiveness and safety of clinical treatment, and reduce the health care cost for patients.

关 键 词：干燥综合征 卡氏肺孢子菌肺炎 磺胺 脱敏试验 药学监护 

分 类 号：R994.11[医药卫生—毒理学]