超声洁治联合抗菌多肽牙周凝胶治疗孕中期妊娠期龈炎的效果观察  

Observation on the therapeutic effect of ultrasonic cleaning combined with antibacterial polypeptide periodontal gel in the treatment of gingivitis in the second trimester of pregnancy

作　　者：吴峥嵘 夏长普[1] 李朝晖[1] WU Zhengrong;XIA Changpu;LI Chaohui(Department of Stomatology,Guangzhou Huadu Maternal and Child Health Center(Huzhong Hospital),Guangdong,Guangzhou 510800,China)

机构地区：[1]广州市花都区妇幼保健院(胡忠医院)口腔科,广东广州510800

出　　处：《中国医药科学》2022年第12期57-61,共5页China Medicine And Pharmacy

基　　金：广东省广州市花都区科技计划项目(20-HDWS-064)。

摘　　要：目的探讨超声洁治联合抗菌多肽牙周凝胶治疗孕中期妊娠期龈炎的临床疗效,为妊娠期龈炎患者提供一种更佳的治疗方案。方法采用前瞻性临床对照研究的方法,选取2020年4月至2021车3月到广州市花都区妇幼保健院口腔科就诊的80例妊娠期龈炎患者作为研究对象,孕16~28周,采用随机数字表法将其分为对照组和观察组,每组各40例,均采用超声洁治术,然后对照组每日餐后使用1%双氧水含漱,每次剂量为10 ml,含漱时间为2~3 min;观察组在龈沟内注入抗菌多肽牙周凝胶,疗程均为4周。记录两组患者治疗前1周及治疗后4周的牙龈指数(GI)、菌斑指数(PLI)、龈沟出血指数(SBI)、牙周探诊深度(PD)、炎症因子水平,评估临床疗效和用药不良反应。结果治疗后4周两组GI、PLI和SBI评分以及PD值均较治疗前降低,且观察组明显低于对照组,差异有统计学意义(P<0.05)。治疗前,两组C反应蛋白(CRP)和肿瘤坏死因子(TNF-α)水平比较,差异无统计学意义(P>0.05);观察组治疗后的TNF-α和CRP水平均低于对照组(P<0.05);观察组的临床总有效率高于对照组(P<0.05),两组均未发生严重的药物不良反应。结论超声洁治联合抗菌多肽牙周凝胶治疗孕中期妊娠期龈炎具有较好的安全性和有效性,值得推广应用。Objective To investigate the therapeutic efficacy of ultrasonic cleaning combined with antibacterial polypeptide periodontal gel in the treatment of gingivitis in the second trimester of pregnancy,so as to provide a better treatment scheme for patients with gingivitis in pregnancy.Methods A total of 80 patients with gingivitis during pregnancy admitted to the department of stomatology in Guangzhou Huadu Maternal and Child Health Center from April 2020 to March 2021 were selected as the research subjects according to the prospective clinical controlled research method.The pregnancy period was 16-28 weeks.They were divided into the control group(n=40)and the observation group(n=40)according to the random number table method.All of them were treated with ultrasonic cleaning.Then,the control group was gargled with 1%hydrogen peroxide every day after meals,with a dose of 10 ml each time and a gar gle time of 2-3 minutes.In the observation group,the antibacterial polypeptide periodontal gel was injected into gingival sulcus.All the course of treatment was 4 weeks.The gingival index(GI),plaque index(PLI),gingival sulcus bleeding index(SBI),periodontal probing depth(PD),levels of inflammatory factors,clinical efficacy and adverse drug reactions were recorded in the two groups of patients at 1 week before treatment and 4 weeks after treatment.Results 4 weeks after treatment,the scores of GI,PLI,SBI and PD in the two groups were all lower than those before treatment,and the observation group was significantly lower than the control group,with statistically significant differences(P<0.05).Before treatment,there were no contrast differences in the levels of C-reactive protein(CRP)and tumor necrosis factor(TNF-α)between the two groups(P>0.05).After treatment,the levels of TNF-αand CRP in the observation group were both lower than those in the control group(P<0.05).The overall clinical response rate of the observation group was higher than that of the control group(P<0.05),and no serious adverse drug reactions occurred in bo

关 键 词：超声洁治 抗菌多肽 牙周凝胶 妊娠期龈炎 

分 类 号：R714.25[医药卫生—妇产科学]