二甲双胍联合诺和锐特充治疗妊娠期糖尿病对血糖指标及安全性的影响  

Effect of metformin combined with NovoRapid FlexPen on blood glucose indexes and safetyin the treatment of gestational diabetes mellitus

作　　者：王红梅[1] WANG Hong-mei(Chifeng Hospital,Chifeng 024000,China)

机构地区：[1]赤峰市医院,024000

出　　处：《中国实用医药》2022年第13期106-108,共3页China Practical Medicine

摘　　要：目的 探究二甲双胍联合门冬胰岛素注射液(商品名:诺和锐特充)治疗妊娠期糖尿病对血糖指标及安全性的影响。方法 110例妊娠期糖尿病患者为研究对象,随机分为观察组与对照组,每组55例。对照组单纯应用诺和锐特充治疗,观察组应用二甲双胍联合诺和锐特充治疗。对比两组治疗前后血糖指标[空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)]及治疗后不良反应发生情况。结果 治疗后,观察组FBG、2 h PBG、HbA1c水平分别为(5.36±0.32)mmol/L、(7.36±0.42)mmol/L、(6.20±0.43)%,均低于对照组的(6.89±0.42)mmol/L、(9.50±1.21)mmol/L、(7.69±0.36)%,差异有统计学意义(P<0.05)。观察组治疗后不良反应发生率5.45%低于对照组的21.82%,差异有统计学意义(P<0.05)。结论 在临床中为妊娠期糖尿病患者选择治疗方案时,选择二甲双胍联合诺和锐特充治疗的临床效果明显,可将患者的血糖水平控制在合理范围内,并进一步减少患者的用药不良反应,值得临床推广。Objective To investigate the effect of metformin combined with insulin aspart injection(trade name:NovoRapid FlexPen)on blood glucose indexes and safetyin the treatment of gestational diabetes mellitus.Methods A total of 110 patients with gestational diabetes mellitus were selected as the research subjects,and were randomly divided into observation group and control group,with 55 cases in each group.The control group was treated with NovoRapid FlexPen alone,while the observation group was treated with metformin combined with NovoRapid FlexPen.Both groups were compared in terms of blood glucose indexes[fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PBG),glycosylated hemoglobin(HbA1c)]before and after treatment and the occurrence of adverse reactions after treatment.Results After treatment,the levels of FBG,2 h PBG and HbA1c in the observation group were(5.36±0.32)mmol/L,(7.36±0.42)mmol/L and(6.20±0.43)%,which were lower than(6.89±0.42)mmol/L,(9.50±1.21)mmol/L,and(7.69±0.36)%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 5.45%in the observation group after treatment was lower than 21.82%in the control group,and the difference was statistically significant(P<0.05).Conclusion Metformin combined with NovoRapid FlexPen has obvious effect in the treatment of gestational diabetes mellitus,and can control the blood glucose level within a reasonable range and further reduce the adverse reactions of patients,which is worthy of clinical promotion.

关 键 词：二甲双胍 门冬胰岛素注射液 妊娠期糖尿病 血糖指标 不良反应 

分 类 号：R714.256[医药卫生—妇产科学]