彩色多普勒超声评价反复自然流产患者子宫内膜容受性的价值及与妊娠结局的相关性  

Value of color Doppler ultrasound in evaluating endometrial receptivity in patients with recurrent spontaneous abortion and its relationship with pregnancy outcome

作　　者：邵琦 沈鲁娜 钱诚 孙一红 SHAO Qi;SHEN Lu-Na;QIAN Cheng(Department of Special Inspection,Ningbo Hospital of Traditional Chinese Medicine,Ningbo,Zhejiang 315000,China)

机构地区：[1]宁波市中医院特检科,浙江宁波315000 [2]宁波市中医院妇科,浙江宁波315000

出　　处：《中国妇幼保健》2022年第9期1720-1723,共4页Maternal and Child Health Care of China

基　　金：浙江省医药卫生科技计划项目(2019KY156)。

摘　　要：目的 研究彩色多普勒超声评价反复自然流产患者子宫内膜容受性的价值及其与妊娠结局的相关性。方法 选取2017年2月—2019年2月宁波市中医院收治的反复自然流产患者77例为研究对象,按照是否继续妊娠分为妊娠组(34例)和流产组(43例)。两组患者均进行彩色多普勒超声检查,比较子宫内膜相关指标,并进行相关性分析。结果 两组患者年龄、流产次数、体质指数、卵泡刺激素及黄体生成素比较,差异均无统计学意义(均P>0.05)。两组患者子宫内膜厚度[妊娠组(8.99±0.74)mm,流产组(9.02±0.75)mm]和容积[妊娠组(3.97±0.78)ml,流产组(3.94±0.80)ml]比较,差异均无统计学意义(t=0.175、0.165,均P>0.05)。两组患者子宫动脉各项血流参数比较,差异均无统计学意义(均P>0.05)。妊娠组患者子宫螺旋动脉血流参数中的搏动指数(PI)、阻力指数(RI)及收缩期峰值血流速度/舒张末期血流速度(S/D)[(0.89±0.06)、(0.55±0.03)及(2.14±0.06)]均低于流产组[(1.41±0.08)、(0.72±0.07)及(3.31±0.09)],差异均有统计学意义(t=31.519、13.219及65.169,均P<0.05)。Spearman相关性分析结果显示,反复自然流产患者继续妊娠与子宫螺旋动脉血流参数中的PI、RI及S/D均呈负相关关系(r=-0.662,P=0.000;r=-0.615,P=0.000;r=-0.624,P=0.000)。结论 彩色多普勒超声评价反复自然流产患者子宫内膜容受性的价值较高,其中子宫螺旋动脉血流参数与妊娠结局密切相关,可作为评估患者是否能够继续妊娠的有效指标,具有一定的临床应用价值。Objective To study the value of color Doppler ultrasound in evaluating endometrial receptivity in patients with recurrent spontaneous abortion and its correlation with pregnancy outcome.Methods 77 patients with recurrent spontaneous abortion who were admitted to Ningbo Hospital of Traditional Chinese Medicine from February 2017 to February 2019 were selected as the research objects.They were divided into pregnancy group(34 cases) and abortion group(43 cases) according to whether or not to continue the pregnancy.Color Doppler ultrasonography was performed in both groups of patients, and endometrial related indicators were compared, and the correlation analysis were carried out.Results Comparison of age, number of abortions, body mass index, follicle-stimulating hormone and luteinizing hormone between the two groups of patients, the differences were not statistically significant(all P>0.05).Comparison of endometrial thickness[pregnancy group(8.99±0.74)mm, abortion group(9.02±0.75)mm] and volume[pregnancy group(3.97±0.78)ml, abortion group(3.94±0.80)ml] between the two groups of patients, the differences were not statistically significant(t=0.175,0.165,all P>0.05).Comparisons of uterine artery blood flow parameters between the two groups of patients, the differences were not statistically significant(all P>0.05).The pulsation index(PI), resistance index(RI) and peak systolic blood flow velocity/end-diastolic blood flow velocity(S/D) of uterine spiral artery blood flow parameters of patients in pregnancy group were[(0.89±0.06),(0.55±0.03) and(2.14±0.06)] were lower than those of patients in abortion group[(1.41±0.08),(0.72±0.07) and(3.31±0.09)], the differences were statistically significant(t=31.519, 13.219 and 65.169, all P<0.05).Spearman correlation analysis results showed that continued pregnancy in patients with recurrent spontaneous abortion was negatively correlated with PI, RI and S/D in uterine spiral artery blood flow parameters(r=-0.662, P=0.000;r=-0.615, P=0.000;r=-0.624, P=0.000).Conclusion Col

关 键 词：反复自然流产 彩色多普勒超声 子宫内膜容受性 妊娠结局 相关性 

分 类 号：R71[医药卫生—妇产科学]