针刺治疗呼吸困难的神经内分泌机制研究进展  

Research progress of neuroendocrine mechanism of acupuncture for dyspnea

作　　者：秦尔奇[1] 梁繁荣[2] 李钰[1] 熊婵[1] 刘业方 郑倩华[2] 张承舜[2] 付娟娟[3] QIN Er-qi;LIANG Fan-rong;LI Yu;XIONG Chan;LIU Ye-fang;ZHENG Qian-hua;ZHANG Cheng-shun;FU Juan-juan(The Third Affiliated Hospital of Chengdu University of TCM/Chengdu Pidu District Hospital of Traditional Chinese Medicine,Chengdu 611730,China;Chengdu University of TCM,Chengdu 610053;Department of Integrated Traditional Chinese and Western Medicine,West China Hospital,Sichuan University,Chengdu 610041)

机构地区：[1]成都中医药大学附属第三医院/成都市郫都区中医医院,成都611730 [2]成都中医药大学,成都610053 [3]四川大学华西医院中西医结合科,成都610041

出　　处：《针刺研究》2022年第6期559-564,共6页Acupuncture Research

基　　金：国家自然科学基金面上项目(No.81870014);四川省科技厅重点研发项目(No.2020YFS0145);四川省科技计划项目应用基础计划项目(No.2016JY0008);四川省中医药管理局项目(No.2020LC0030)。

摘　　要：本文对近20年针刺治疗呼吸困难的相关研究及可能的神经内分泌机制从中枢和外周迷走神经、神经递质、呼吸肌功能和抗抑郁焦虑作用等方面进行综述。研究显示针刺调控呼吸困难的中枢响应区域与针刺镇痛影响的区域相似,而针刺可通过促进内源性阿片肽类物质的释放,以及对自主神经、杏仁核、下丘脑-垂体-肾上腺轴的调节而产生治疗作用。The paper reviewed the relevant studies on dyspnea treated with acupuncture over the past 20years,as well as the underlying neuroendocrine mechanism from the perspective of central and peripheral vagus nerves,neurotransmitter,respiratory muscle function and anti-depression-anxiety function.It revealed that the central response area was regulated by acupuncture in treatment of dyspnea,which is similar to the area affected in acupuncture analgesia.Additionally,acupuncture generates its therapeutic effects on dyspnea through promoting the release of endogenous opioid peptides and the regulation of autonomic nerve,amygdale and hypothalamic-pituitary-adrenal axis.

关 键 词：呼吸困难 针刺 神经内分泌机制 Β-内啡肽 

分 类 号：R246.1[医药卫生—针灸推拿学]