高荧光氮掺杂碳点用于卡马西平和琥乙红霉素的测定  

High Fluorescent Nitrogen Doped Carbon Dots for the Determination of Carbamazepine and Erythromycin Ethylsuccinate

作　　者：孙雪花[1] 强瑜 田锐[1] 张锦婷 高楼军[1] SUN Xuehua;QIANG Yu;TIAN Rui;ZHANG Jinting;GAO Loujun(Key Lab of Chemical Reaction Engineering of Shaanxi Province,College of Chemistry and Chemical Engineering,Yan’an University,Yan’an 716000)

机构地区：[1]陕西省化学反应工程重点实验室,延安大学化学与化工学院,陕西延安716000

出　　处：《分析科学学报》2022年第3期309-314,共6页Journal of Analytical Science

基　　金：陕西省科技厅自然科学基金(No.2020JQ-789);陕西省教育厅重点科学研究项目(No.20JS156)。

摘　　要：本文对一步水热法合成的氮掺杂麦芽糖蓝色荧光碳点(NCDs)进行研究,发现NCDs表面具有丰富的官能团,其水溶性良好,光稳定性强,荧光量子产率可达30.42%,高于掺杂前。基于药物卡马西平和琥乙红霉素对NCDs的荧光具有选择性和有效地猝灭作用,据此以NCDs为荧光探针,建立了一种测定卡马西平和琥乙红霉素的荧光分析新方法。该方法中卡马西平和琥乙红霉素溶液的线性范围分别为0.01~1.1μg/mL和0.01~1.7μg/mL,检出限分别为5.0 ng/mL和8.0 ng/mL。A nitrogen doped maltose blue fluorescent of carbon dots(NCDs) were synthesized by a one-step hydrothermal method.It was found that the NCDs had rich functional groups on the surface, so they had good water-solubility and strong optical stability, with a fluorescence quantum yield up to 30.42% higher than pre-doping.Based on this, the fluorescence of NCDs was selectively and effectively quenched by the drugs carbamazepine(CAMP) and erythromycin(EMES).The quenching mechanisms might be assumed to the static quenching.Based on this principle, a novel fluorescence probe was developed for the determination of CAMP and EMES.At the same time, the proposed probe showed excellent sensitivity and selectivity towards CAMP and EMES with wide linear ranges of 0.01-1.1 μg/mL and 0.01-1.7 μg/mL,and the detection limits of 5.0 ng/mL and 8.0 ng/mL.

关 键 词：碳点 氮掺杂 卡马西平 琥乙红霉素 荧光猝灭 

分 类 号：O657.39[理学—分析化学]