葡萄糖酸氯己定消毒液的亚急性毒性观察  

Observation on the subacute toxicity of a chlorhexidine gluconate disinfectant

作　　者：郑云燕[1] 严峻[1] 朱周靓[1] 夏勇[1] 张世鑫[1] 孟真[1] ZHENG Yun-yan;YAN Jun;ZHU Zhou-jing;XIA Yong;ZHANG Shi-xin;MENG Zhen(Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou Zhejiang 310051,China)

机构地区：[1]浙江省疾病预防控制中心,浙江杭州310051

出　　处：《中国消毒学杂志》2022年第6期420-422,共3页Chinese Journal of Disinfection

摘　　要：目的了解葡萄糖酸氯己定消毒液的安全性。方法以40、200和1000 mg/(kg·bw)3个剂量葡萄糖酸氯己定消毒液灌胃SD大鼠,每天1 mL/0.1(kg·bw),持续28 d,观察葡萄糖酸氯己定对SD大鼠的亚急性毒性作用。结果葡萄糖酸氯己定对SD雌雄大鼠急性经口LD_(50)大于5000 mg/(kg·bw)。28 d经口试验结果显示,SD大鼠生长发育良好,未观察到中毒表现。与对照组比较,SD大鼠血液学、血清生化指标差异均无统计学意义(P>0.05);病理学结果显示,主要脏器未发现有意义的病理性改变。结论在本实验条件下,葡萄糖酸氯己定对SD大鼠属实际无毒类。亚急性毒性试验未发现葡萄糖酸氯己定对SD大鼠有明显毒性作用。Objective To investigate the safety of the chlorhexidine gluconate(CHG)disinfectant.Methods The 28-day repeated dose oral test was employed to observe the sub-acute toxicity of CHG disinfectant in SD rats.Results The acute oral LD_(50) in female and male rats of the CHG disinfectant was higher than 5000 mg/kg·bw.During the period of 28 days,all rats of the three exposure groups grew well and no toxic sign were observed.No significant differences in the hematological parameters and serum biochemical parameters in three exposure groups compared to the control group(P>0.05).The histopathological examination showed that no obvious exposure-related pathological changes in all exposure rats.Conclusion Under this experimental condition,the CHG disinfectant is actual non-toxic after an acute oral exposure.Subacute toxicity test shows no abnormality and toxic sign to SD rats.

关 键 词：葡萄糖酸氯己定 SD大鼠 亚急性毒性 

分 类 号：R187.2[医药卫生—流行病学]