硫酸吲哚酚在慢性肾病并发症中的作用  

Roles of indoxyl sulfate in complications of chronic kidney disease

作　　者：朱新如 黄鑫 ZHU Xinru;HUANG Xin(New Drug Screening Center,Institute of Pharmaceutical Sciences,China Pharmaceutical University,Nanjing 210009,Jiangsu,China;Jiangsu Center for Pharmacodynamics Research and Evaluation,China Pharmaceutical University,Nanjing 210009,Jiangsu,China;Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education,China Pharmaceutical University,Nanjing 210009,Jiangsu,China)

机构地区：[1]中国药科大学药物科学研究院新药筛选中心,江苏南京210009 [2]江苏省药效研究与评价服务中心,江苏南京210009 [3]中国药科大学药物质量与安全预警教育部重点实验室,江苏南京210009

出　　处：《中国临床药理学与治疗学》2022年第6期672-679,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(82174072)。

摘　　要：慢性肾病(chronic kidney disease,CKD)是全球性公共卫生问题,其发生发展与体内尿毒症毒素暴露密切相关。硫酸吲哚酚(indoxyl sulfate,IS)是一种肠源性的蛋白结合型尿毒症毒素,由于CKD患者肾脏排泄功能被破坏,IS在CKD患者体内蓄积。IS不仅促进CKD进展,还诱导其他组织器官病变,进而引起CKD相关的并发症。本文综述了IS对CKD患者血管、肌肉、骨骼以及大脑的影响及其相应的机制,并总结通过清除IS治疗CKD的方法。Chronic kidney disease is a global public health problem,and its occurrence and development are closely related to the exposure of uremic toxins in vivo.Indoxyl sulfate is one of protein-bound enterogenous uremic toxin,it significantly accumulates in patients with chronic kidney disease as renal function declines.Indoxyl sulfate not only promotes the progression of chronic kidney disease,but also induces pathological changes in other tissues and organs,causing complications in other organs related to chronic kidney disease.This article mainly reviews the effect of indoxyl sulfate on blood vessels,muscle,skeleton and brain and their mechanisms,and summarizes chronic kidney disease treatment by clearing indoxyl sulfate.

关 键 词：慢性肾病 尿毒症毒素 慢性肾病并发症 硫酸吲哚酚 

分 类 号：R692[医药卫生—泌尿科学]