凝血纤溶系统失衡与特发性肺间质纤维化发病机制及治疗的研究进展  

Research progress on the imbalance of coagulation and fibrinolysis system and the pathogenesis and treatment of idiopathic pulmonary interstitial fibrosis

作　　者：孙莹[1] 余勤[2] SUN Ying;YU Qin(First Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu,China;Department of Respiratory and Critical Medicine,First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院呼吸与危重症医学科,甘肃兰州730000

出　　处：《中国临床药理学与治疗学》2022年第6期689-695,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：甘肃省科技计划项目(18YF1FA106)。

摘　　要：特发性肺间质纤维化(IPF)是一种进行性间质性肺疾病,其预后比许多癌症都要差,发病机制复杂并且尚未明确。在肺纤维化的动物模型以及IPF的患者中,已证实均存在凝血系统以及纤溶系统的失衡。本文阐述了凝血纤溶系统失衡在IPF中的可能损伤机制,为IPF的治疗提供新思路。Idiopathic pulmonary interstitial fibrosis(IPF)is a progressive interstitial lung disease.Its prognosis is worse than that of many cancers.Its pathogenesis is complex and unclear.The imbalance of coagulation system and fibrinolysis system was confirmed in both animal models of pulmonary fibrosis and patients with IPF.This paper expounds the possible injury mechanism of the imbalance of coagulation and fibrinolysis system in IPF,and provides a new idea for the treatment of IPF.

关 键 词：特发性肺间质纤维化血小板 凝血因子 尿激酶纤溶酶原激活物 纤溶酶原激活物抑制物 

分 类 号：R581.2[医药卫生—内分泌] R563[医药卫生—内科学]