成纤维细胞生长因子19在肥胖和糖尿病中的作用  

Roles of fibroblast growth factor 19 in obesity and diabetes mellitus

作　　者：张艳君 李桂梅[1,3] Zhang Yanjun;Li Guimei(Department of Pediatric Endocrinology,Shandong Provincial Hospital,Cheeloo College of Medicine,Shandong University,Ji'nan 250021,China;Department of Pediatrics,Binzhou Medical University Hospital,Binzhou 256603,China;Department of Pediatric Endocrinology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Taian 271016,China)

机构地区：[1]山东大学附属省立医院儿科内分泌综合科,济南250021 [2]滨州医学院附属医院儿科,256603 [3]山东第一医科大学附属省立医院儿科内分泌综合科,泰安271016

出　　处：《国际生物医学工程杂志》2021年第6期491-495,512,共6页International Journal of Biomedical Engineering

基　　金：山东省医药卫生科技发展计划项目(2017WS038)。

摘　　要：成纤维细胞生长因子19(FGF19)是一种内分泌激素,主要受胆汁酸的调节。FGF19有助于减轻体质量,多种减肥措施均通过提高FGF19水平来实现,且FGF19可逆转肥胖引起的线粒体功能障碍。糖尿病的主要致病机制为胰岛素抵抗和胰岛β细胞缺陷,由此可引起微血管病变和心血管疾病。FGF19可从根本上保护胰岛β细胞功能、改善胰岛素抵抗、增加胰岛素敏感性,并通过不依赖胰岛素活性的途径达到降血糖的目的。糖尿病患者会不同程度地出现并发症,FGF19可通过改善糖尿病心肌细胞的能量代谢发挥保护糖尿病心肌细胞的作用,其可能在糖尿病视网膜病变及糖尿病肾病发生发展过程中起保护性作用。FGF19在治疗肥胖、控制糖尿病及其并发症的过程中发挥着重要作用,有望成为治疗肥胖和糖尿病的新策略。Fibroblast growth factor 19(FGF19)is an endocrine hormone and it's primarily regulated by bile acids.FGF19 helps to reduce body weight,a variety of weight loss mechanism are achieved by increasing the level of FGF19.FGF19 can reverse mitochondrial dysfunction caused by obesity.The main pathogenesis of diabetes is insulin resistance and isletβcell defects,which can cause microangiopathy and cardiovascular diseases.FGF19 can fundamentally protect the function of isletβcells,improve insulin resistance,increase insulin sensitivity,and achieve the purpose of reducing blood glucose by insulin-independent manner.Diabetic patients have different degrees of complications.FGF19 can protect the diabetic cardiomyocytes by improving the energy metabolism of diabetic cardiomyocytes.It may play a protective role in the development of diabetic retinopathy and diabetic nephropathy.The results of this review paper show that FGF19 plays an important role in the treatment of obesity,diabetes and its complications,and regulating FGF19 is expected to become a new strategy for the treatment of obesity and diabetes.

关 键 词：糖尿病 肥胖症 成纤维细胞生长因子19 并发症 

分 类 号：R587.2[医药卫生—内分泌] R589.2[医药卫生—内科学]