^(90)Y树脂微球治疗患者尿液中 ^(90)Y放射性活度检测和分析  

Measurement and analysis of ^(90)Y radioactivity in urine of patients treated with ^(90)Y resin microspheres

作　　者：练德幸[1] 寇珊珊 陆见霏 晁俊 朱仔运 张庆召[1] 侯长松[1] Lian Dexing;Kou Shanshan;Lu Jianfei;Chao Jun;Zhu Zaiyun;Zhang Qingzhao;Hou Changsong(Key Laboratory of Radiological Protection and Nuclear Emergency,China CDC,National Institute for Radiological Protection,Chinese Center for Disease Control and Prevention,Beijing 100088,China;Hainan Center for Disease Control and Prevention,Haikou 570203,China)

机构地区：[1]中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室,北京100088 [2]海南省疾病预防控制中心,海口570203

出　　处：《中华放射医学与防护杂志》2022年第6期460-463,共4页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的:研究患者接受 ^(90)Y树脂微球选择性内放射治疗(SIRT)后48 h内所排泄尿液中 ^(90)Y的放射性活度,为术后患者排泄物的管理提供建议。 方法:收集3名患者在术后0~24 h和24~48 h两个时间段内排泄的尿液,并对尿液中的 ^(90)Y放射性活度进行检测和分析。 结果:3名患者术后0~24 h和24~48 h尿液中的 ^(90)Y放射性活度排泄量分别为(1 266±258)kBq/GBq和(140±106)kBq/GBq, ^(90)Y放射性活度浓度分别为(640±113)kBq/L和(53±12)kBq/L。 结论:^(90)Y树脂微球治疗术后肝癌患者0~24 h排泄尿液中的 ^(90)Y放射性活度比24~48 h高。术后患者可通过增加排泄尿量的方式来加速排出体内游离的 ^(90)Y;患者住院期间的排泄物应按照HJ 1188-2020《核医学辐射防护与安全要求》的要求处理。Objective To evaluate ^(90)Y activity concentration in renal excretions during the first 48 hours after being treated with ^(90)Y resin microspheres seleceive internal radiation therapy(SIRI)and to provide advice on the management of patient excreta after surgery.Methods After surgery,urine excreted from 3 patients during 0-24 h and 24-48 h was collected respectively,and the ^(90)Y activity concentration in urine was tested and analyzed.Results ^(90)Y radioctivity in the urine excreted from 3 patients after surgery was(1266±258)kBq/GBq during 0-24 h and(140±106)kBq/GBq during 24-48 h,respectively,and ^(90)Y activity concentration were(640±113)kBq/L during 0-24 h and(53±12)kBq/L during 24-48 h.Conclusions ^(90)Y radioactivity in patient′s urine excreted at 1 d was about 10 times higher than that at 2 d.After surgery,patients can accelerate the reduction of free ^(90)Y activity by increasing excretion.Urine excreted by the patients during hospitalization should be handled in accordance with the requirements of the national standard HJ 1188-2021 Radiation protection and safety requirements for nuclear medicine.

关 键 词：^(90)Y树脂微球 排泄尿液 放射性活度 

分 类 号：R446.12[医药卫生—诊断学]