补骨脂环己烷溶性化学成分的研究  

Study on chemical constituents from cyclohexane soluble part of Psoraleae Fructus

作　　者：杨秀伟[1] 吕倩 许青霞 徐嵬[1] 张英涛[1] YANG Xiu-wei;LYU Qian;XU Qing-xia;XU Wei;ZHANG Ying-tao(State Key Laboratory of Natural and Biomimetic Drugs,Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)

机构地区：[1]北京大学药学院天然药物学系,天然药物及仿生药物国家重点实验室,北京100191

出　　处：《中草药》2022年第11期3269-3279,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81773865)。

摘　　要：目的研究补骨脂Psoraleae Fructus 70%乙醇水提取物的环己烷溶性部分的化学成分。方法采用硅胶、高效液相色谱等柱色谱方法进行分离纯化,通过化合物的谱学数据鉴定其结构。结果从补骨脂70%乙醇水提取物的环己烷溶性部分分离出21个化合物,分别鉴定为补骨脂醚(1)、对羟基苯甲醛(2)、邻苯二甲酸二异辛酯(3)、补骨脂醚酚G(4)、补骨脂醚酚H(5)、双补骨脂酚V(6)、双补骨脂酚I(7)、双补骨脂酚H(8)、双补骨脂酚F(9)、双补骨脂酚D(10)、双补骨脂酚G(11)、豆甾醇(12)、补骨脂查耳酮(13)、补骨脂定(14)、补骨脂二氢黄酮甲醚(15)、异补骨脂素(16)、补骨脂素(17)、豆甾醇-3-O-β-D-吡喃葡萄糖苷-6′-O-棕榈酸酯(18)、4-羟基合生果素(19)、新补骨脂宁(20)和6-异戊烯基柚皮素(21)。结论化合物1、4、5和6为4个新的化合物。Objective To study chemical constituents of cyclohexane soluble part in 70%ethanol aqueous extract of Psoraleae Fructus(the fruits of Psoralea corylifolia).Methods The compounds were separated and purified by silica gel and high performance liquid column chromatographies,and their structures were determined by spectroscopic data analyses.Results Twenty-one compounds were obtained and identified as psoracorylifether(1),p-hydroxybenzaldehyde(2),diisooctyl phthalate(3),psoracorylifol G(4),psoracorylifol H(5),bisbakuchiol V(6),bisbakuchiol I(7),bisbakuchiol H(8),bisbakuchiol F(9),bisbakuchiol D(10),bisbakuchiol G(11),stigmasterol(12),bavachalcone(13),psoralidin(14),bavachinin(15),isopsoralen(16),psoralen(17),stigmasterol-3-O-β-D-glucopyranosyl-6′-O-palmitate(18),4-hydroxylonchocarpin(19),neocorylin(20),and 6-prenylnaringenin(21),respectively.Conclusion Compounds 1,4,5,and 6 are four new compounds.

关 键 词：补骨脂 豆科 补骨脂醚 补骨脂醚酚G 补骨脂醚酚H 双补骨脂酚V 

分 类 号：R284.1[医药卫生—中药学]