常见甘味中药抗糖尿病作用机制研究进展  

Research progress on anti-diabetic mechanism of common sweet-taste herbs

作　　者：李丛宇 曹世杰 邱峰[1,2] 齐学洁[1] 康宁[2,3] LI Cong-yu;CAO Shi-jie;QIU Feng;QI Xue-jie;KANG Ning(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中药学院,天津301617 [2]天津中医药大学组分中药国家重点实验室,天津301617 [3]天津中医药大学中西医结合学院,天津301617

出　　处：《中草药》2022年第11期3531-3537,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81430095);国家自然科学基金资助项目(82030116)。

摘　　要：糖尿病,中医称为消渴病,研究发现五味中药中甘味中药治疗糖尿病的应用频率最高。在中药五味理论中,甘味药具有补益和中的功效,符合“滋阴”“健脾”的糖尿病中医治则。综合近5年来国内外相关文献,对甘味中药治疗糖尿病的药理机制进行归纳总结,主要与调节糖脂代谢、保护胰岛组织、改善胰岛素抵抗、抑制机体炎症因子、提升机体抗氧化能力及调节肠道菌群等有关,以期丰富甘味中药治疗糖尿病的科学内涵,为今后开展相关研究提供理论依据。Diabetes is called Xiaoke disease in the theory of traditional Chinese medicine.Studies have found that among the five flavors of traditional Chinese medicines,sweet-taste herbs were the most frequently used in treatment of diabetes.According to the theory of five flavors of traditional Chinese medicine,sweet-taste herbs have the effect of tonifying and mediating that is in line with the principles of“nourishing yin”and“invigorating spleen”for diabetes.Pharmacological mechanism of sweet-taste herbs in treatment of diabetes was summarized in this paper based on relevant literatures at home and abroad in recent five years.It was mainly related to regulating glucose and lipid metabolism,protecting islet tissue,improving insulin resistance,inhibiting inflammatory factors,enhancing antioxidant capacity and regulating gut microbiota,in order to enrich the scientific connotation of treating diabetes with sweet-taste herbs and provide a theoretical basis for related research in the future.

关 键 词：糖尿病 消渴病 甘味中药 糖脂代谢 胰岛素信号通路 炎症 氧化应激 肠道菌群 

分 类 号：R282.710.5[医药卫生—中药学]