毛裂蜂斗菜中的1个新的倍半萜化合物  

A new sesquiterpenoid from Petasites tricholobus

作　　者：李炳祎 张勇[2,3,4] 贾琦[1] 李医明 朱维良[2,3,4] LI Bing-yi;ZHANG Yong;JIA Qi;LI Yi-ming;ZHU Wei-liang(School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization,CAS Laboratory of Chemistry of Plant Resources in Arid Regions,Xinjiang Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Urumqi 830011,China;CAS Key Laboratory of Receptor Research,Stake Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]上海中医药大学中药学院,上海201203 [2]中国科学院新疆理化技术研究所,中国科学院干旱区植物资源化学重点实验室,省部共建新疆特有药用资源利用国家重点实验室培育基地,新疆乌鲁木齐830011 [3]中国科学院上海药物研究所,新药研究国家重点实验室,中科院受体结构与功能重点实验室,上海201203 [4]中国科学院大学,北京100049

出　　处：《中草药》2022年第12期3581-3586,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81603270)。

摘　　要：目的 研究菊科蜂斗菜属植物毛裂蜂斗菜Petasites tricholobus全草中倍半萜类化学成分。方法 采用正相硅胶、反相硅胶、葡聚糖凝胶、微孔树脂等多种柱色谱填料进行分离纯化,并运用MS、NMR、UV、IR等现代波谱分析技术对化合物结构进行鉴定。结果 从毛裂蜂斗菜50%乙醇提取物中分离得到5个倍半萜类化合物,分别鉴定为1α-(cismethylthioacryloyloxy)-8α-angeloyloxy-3β,4β-epoxy-bisabola-7(14),10-diene(1)、bakkenolide IIIb(2)、monoketone(3)、japonipene C(4)和petatewalide A(5)。结论 化合物1为新化合物,命名为毛裂蜂斗菜素;化合物2~5均为首次从毛裂蜂斗菜中分离得到。Objective To study sesquiterpenoids from the herb of Petasites tricholobus of Compositae family. Methods The compounds were isolated and purified by silica gel, ODS, Sephadex LH-20, MCI, etc. Their structures were identified by extensive analysis of MS, NMR, UV, IR data and so on. Results Five sesquiterpenoids were isolated from the 50% ethanol extract of P. tricholobus. and identified as 1α-(cis-methylthioacryloyloxy)-8α-angeloyloxy-3β,4β-epoxy-bisabola-7(14),10-diene(1), bakkenolide IIIb(2), monoketone(3), japonipene C(4) and petatewalide A(5). Conclusion Compound 1 is a new sesquiterpenoid named petatricholide, and compounds 2—5 were isolated from P. tricholobus for the first time.

关 键 词：菊科 蜂斗菜属 毛裂蜂斗菜 倍半萜 毛裂蜂斗菜素 bakkenolide IIIb monoketone 

分 类 号：R284.1[医药卫生—中药学]